biostudies-literatureUnknown16(8)Zeng YPreparation and characterization of a series of oligo(ethylene glycol)methylether functionalized alkynyl gold(i) complexes capped with AuPPh₃ (1a-1d) or dppfAu₂ (dppf, 1,1'-<i>bis</i>(diphenyphosphino)ferrocene) (2a-2d) have been accomplished. The structures of 1b and 1c were established by X-ray crystallography. Their <i>in vitro</i> antitumor activities were measured by the CCK8 method against A549 and HeLa cells. The studies indicated that the cytotoxic activity <i>in vitro</i> was fine-tuned by modification of both the gold(i) centers and the oligo(ethylene glycol)methylether ancillary ligands. Compared to the dppfAu₂ series, the AuPPh₃ series showed better cytotoxicity. Especially, complex 4-(OCH₂CH₂OCH₂CH<suRSC advances7092-7096https://www.ebi.ac.uk/biostudies/studies/S-EPMC12865784biostudies-literatureSynthesis and antitumor activity of mono and digold(i) alkynyl complexes with oligo(ethylene glycol)methylether.PMC12865784Chen QMZhou PZhang JFRen WXMou XZeng YZheng FWu XHJin LfalseSynthesis and antitumor activity of mono and digold(i) alkynyl complexes with oligo(ethylene glycol)methylether.Preparation and characterization of a series of oligo(ethylene glycol)methylether functionalized alkynyl gold(i) complexes capped with AuPPh₃ (1a-1d) or dppfAu₂ (dppf, 1,1'-<i>bis</i>(diphenyphosphino)ferrocene) (2a-2d) have been accomplished. The structures of 1b and 1c were established by X-ray crystallography. Their <i>in vitro</i> antitumor activities were measured by the CCK8 method against A549 and HeLa cells. The studies indicated that the cytotoxic activity <i>in vitro</i> was fine-tuned by modification of both the gold(i) centers and the oligo(ethylene glycol)methylether ancillary ligands. Compared to the dppfAu₂ series, the AuPPh₃ series showed better cytotoxicity. Especially, complex 4-(OCH₂CH₂OCH₂CH<su2026-01-01T00:00:00Z2026 Feb2026-07-15T06:43:09.932Z2026-06-30T03:21:57.987ZS-EPMC128657844164123210.1039/d5ra08951d