{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Farrow E"],"funding":["National Institute of Neurological Disorders and Stroke","NIDCR NIH HHS","Foundation for the National Institutes of Health","NINDS NIH HHS","National Institute of Dental and Craniofacial Research","Cincinnati Children's Hospital Medical Center","NIGMS NIH HHS"],"pagination":["35-51"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12866604"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["532"],"pubmed_abstract":["Animal models have demonstrated a critical role of the homeodomain transcription factor Genetic-Screened Homeobox 2 (‍‍‍‍‍‍‍‍‌‌‌‌‌‌Gsx‍‍2‍‍‍‍‍‍) in the developing basal ganglia. Moreover, recent clinical genetic studies have shown that GSX2 patient variants are associated with severe neurological symptoms and basal ganglia dysgenesis. Unfortunately, technical limitations with existing animal models, such as progenitor heterogeneity and limited temporal control, have impeded the investigation of direct regulatory targets. In this study, we engineered a Dox-inducible human embryonic stem cell (‍‍hESC) line to investigate the function of GSX2 in directed differentiation cultures that model developing lateral ganglionic eminence-like (LGE-like) progenitors. Transcriptomic, chromatin accessibil"],"journal":["Developmental biology"],"pubmed_title":["An inducible system to study the regulatory functions of GSX2 in human lateral ganglionic eminence-like progenitors."],"pmcid":["PMC12866604"],"funding_grant_id":["R35 GM158075","R01 NS124660","R35 DE07557","F31 DE033565"],"pubmed_authors":["Brugmann SA","Tchieu J","Rao S","Campbell K","Han SJY","Gebelein B","Lim HW","Farrow E","Huynh C","Chang X"],"additional_accession":[]},"is_claimable":false,"name":"An inducible system to study the regulatory functions of GSX2 in human lateral ganglionic eminence-like progenitors.","description":"Animal models have demonstrated a critical role of the homeodomain transcription factor Genetic-Screened Homeobox 2 (‍‍‍‍‍‍‍‍‌‌‌‌‌‌Gsx‍‍2‍‍‍‍‍‍) in the developing basal ganglia. Moreover, recent clinical genetic studies have shown that GSX2 patient variants are associated with severe neurological symptoms and basal ganglia dysgenesis. Unfortunately, technical limitations with existing animal models, such as progenitor heterogeneity and limited temporal control, have impeded the investigation of direct regulatory targets. In this study, we engineered a Dox-inducible human embryonic stem cell (‍‍hESC) line to investigate the function of GSX2 in directed differentiation cultures that model developing lateral ganglionic eminence-like (LGE-like) progenitors. Transcriptomic, chromatin accessibil","dates":{"release":"2026-01-01T00:00:00Z","publication":"2026 Apr","modification":"2026-07-15T11:49:57.834Z","creation":"2026-07-06T03:08:45.401Z"},"accession":"S-EPMC12866604","cross_references":{"pubmed":["41512913"],"doi":["10.1016/j.ydbio.2026.01.005"]}}