biostudies-literatureWang XShenzhen Medical Research FundsArthritis Australia and an NHMRC Investigator Grant Leadership 2Guangdong Basic and Applied Basic Research FoundationNational Natural Science Foundation of China for Distinguished Young ScholarsBasic and Applied Basic Research Foundation of Guangdong ProvinceNational Science Foundation of ChinaChina Postdoctoral Science FoundationNational Natural Science Foundation of ChinaKey Project of the National Science Foundation of ChinaNational Key Research and Development Program of ChinaScience and Technology Projects in GuangzhouPostdoctoral Fellowship Program of CPSFe12020https://www.ebi.ac.uk/biostudies/studies/S-EPMC12866873biostudies-literatureUnknown13(7)Gut microbiota dysbiosis and associated host immuno-metabolic disorders may play a role in knee synovitis. Herein, integrated multi-omics analyses of stool and blood samples from subjects from Pearl River Osteoarthritis Cohort (PROC, N = 207) are conducted to explore the potential gut-joint axis. Specifically, gut metagenomics, serum metabolomics and plasma proteomics are carried out. Knee synovitis is identified by magnetic resonance imaging. A total of 87 synovitis cases are identified in PROC, which are characterized by increased Firmicutes/Bacteroidetes (F/B) ratio. Alterations in microbial functions of both leucine and geraniol degradation are closely associated with increased serum 3-hydroxyisovaleric acid and decreased geranic acid. These perturbations are significantly correlated wAdvanced science (Weinheim, Baden-Wurttemberg, Germany)Multi-Omics Reveal the Dysregulated Gut-Joint Axis in Knee Synovitis: Data from Two Osteoarthritis Studies in China.PMC1286687382373653A24010312023YFE02097002023A1515110748GZC202310592024A15150117942024A04J51692024M7613261194737825300838257282582325035Hu SLiu JLi JWen ZZhu ZHuang JDing CLu ZTuan RSHunter DJSun ZLiu YRuan JCao XLi SLi ZAXie JShi DWang XCao PSun HChen TfalseMulti-Omics Reveal the Dysregulated Gut-Joint Axis in Knee Synovitis: Data from Two Osteoarthritis Studies in China.Gut microbiota dysbiosis and associated host immuno-metabolic disorders may play a role in knee synovitis. Herein, integrated multi-omics analyses of stool and blood samples from subjects from Pearl River Osteoarthritis Cohort (PROC, N = 207) are conducted to explore the potential gut-joint axis. Specifically, gut metagenomics, serum metabolomics and plasma proteomics are carried out. Knee synovitis is identified by magnetic resonance imaging. A total of 87 synovitis cases are identified in PROC, which are characterized by increased Firmicutes/Bacteroidetes (F/B) ratio. Alterations in microbial functions of both leucine and geraniol degradation are closely associated with increased serum 3-hydroxyisovaleric acid and decreased geranic acid. These perturbations are significantly correlated w2026-01-01T00:00:00Z2026 Feb2026-07-15T06:32:27.741Z2026-06-30T03:22:07.755ZS-EPMC128668734135446210.1002/advs.202512020