biostudies-literatureUnknown20(2)Trippler L<h4>Background</h4>The Zanzibar islands, Tanzania, have eliminated schistosomiasis as a public health problem since 2017 and need to rethink their intervention strategies to ensure that the progress made is sustained and advanced. We evaluated the performance of a novel surveillance-response approach for interrupting Schistosoma transmission on Pemba Island from 2020-2024.<h4>Methodology</h4>In low-prevalence implementation units (IUs), surveillance-response interventions were implemented, which consisted of active and reactive case finding, treatment of S. haematobium-positive individuals, and reactive snail control. The performance of the surveillance-response interventions was measured by sensitivity, timeliness and impact on prevalence. Annual cross-sectional surveys were conducted in PLoS neglected tropical diseasese0013947https://www.ebi.ac.uk/biostudies/studies/S-EPMC12867264biostudies-literatureEvaluation of surveillance-response interventions for Schistosoma haematobium elimination on Pemba Island, Tanzania: A 4-year intervention study with repeated cross-sectional surveys.PMC12867264Ali SMTrippler LNajim SOKnopp SAme SMJuma SHattendorf JKhamis KSKabole FAli MNSuleiman KRfalseEvaluation of surveillance-response interventions for Schistosoma haematobium elimination on Pemba Island, Tanzania: A 4-year intervention study with repeated cross-sectional surveys.<h4>Background</h4>The Zanzibar islands, Tanzania, have eliminated schistosomiasis as a public health problem since 2017 and need to rethink their intervention strategies to ensure that the progress made is sustained and advanced. We evaluated the performance of a novel surveillance-response approach for interrupting Schistosoma transmission on Pemba Island from 2020-2024.<h4>Methodology</h4>In low-prevalence implementation units (IUs), surveillance-response interventions were implemented, which consisted of active and reactive case finding, treatment of S. haematobium-positive individuals, and reactive snail control. The performance of the surveillance-response interventions was measured by sensitivity, timeliness and impact on prevalence. Annual cross-sectional surveys were conducted in 2026-01-01T00:00:00Z2026 Feb2026-07-14T21:26:03.888Z2026-06-25T03:07:38.552ZS-EPMC128672644163279010.1371/journal.pntd.0013947