biostudies-literatureBaldenius MDeutsche ForschungsgemeinschaftRP105759https://www.ebi.ac.uk/biostudies/studies/S-EPMC12867482biostudies-literatureUnknown14In the peripheral nervous system, sensory and motor axons are generally covered by wrapping glial cell processes. This neuron-glia interaction requires an intricate coordination of glial growth and differentiation. How this is controlled molecularly remains largely unknown. At the example of <i>Drosophila</i> larval nerves, we show that glial growth, which occurs without any cell division, is initially triggered by the FGF-receptor tyrosine kinase Heartless (Htl). In a screen for genes acting downstream of activated FGF-receptor, we identified the large membrane protein Uninflatable (Uif), which supports the growth of excessive plasma membrane domains but does not support glial axon wrapping. Uif is also known to inhibit Notch. Surprisingly, we find that Notch signaling is required in posteLifeThe &lt;i&gt;Drosophila&lt;/i&gt; EGF domain protein uninflatable sets the switch between wrapping glia growth and axon wrapping instructed by Notch.PMC12867482SFB 1348 B5Baldenius MZipfel JKottmeier RKautzmann SKlambt CfalseThe &lt;i&gt;Drosophila&lt;/i&gt; EGF domain protein uninflatable sets the switch between wrapping glia growth and axon wrapping instructed by Notch.In the peripheral nervous system, sensory and motor axons are generally covered by wrapping glial cell processes. This neuron-glia interaction requires an intricate coordination of glial growth and differentiation. How this is controlled molecularly remains largely unknown. At the example of <i>Drosophila</i> larval nerves, we show that glial growth, which occurs without any cell division, is initially triggered by the FGF-receptor tyrosine kinase Heartless (Htl). In a screen for genes acting downstream of activated FGF-receptor, we identified the large membrane protein Uninflatable (Uif), which supports the growth of excessive plasma membrane domains but does not support glial axon wrapping. Uif is also known to inhibit Notch. Surprisingly, we find that Notch signaling is required in post2026-01-01T00:00:00Z2026 Feb2026-07-14T21:03:48.408Z2026-06-25T03:08:15.913ZS-EPMC128674824163252110.7554/eLife.105759