{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Pires IS"],"funding":["Howard Hughes Medical Institute","Foundation for the National Institutes of Health","Foundation for the National Institutes of Health (Foundation for the National Institutes of Health, Inc.)","Ragon Institute of MGH, MIT and Harvard","NCI NIH HHS","MIT | Deshpande Center for Technological Innovation, Massachusetts Institute of Technology"],"pagination":["322-334"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12867765"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["25(2)"],"pubmed_abstract":["Immunotherapies such as immune checkpoint inhibitors are effective in treating several advanced cancers, but these treatments have had limited success in metastatic ovarian cancer. Here we engineered liposomal nanoparticles carrying a poly-ʟ-arginine/poly-ʟ-glutamate coating that promotes their binding and retention on the surface of ovarian cancer cells. Covalent anchoring of the potent immunostimulatory cytokine interleukin-12 (IL-12) to phospholipid headgroups of the liposome core enabled the polymer-coated particles to concentrate IL-12 in disseminated ovarian cancer tumours following intraperitoneal administration. Shedding of the layer-by-layer coating and serum-protein-mediated extraction of IL-12-conjugated lipids from the liposomal core over time enabled IL-12 to disseminate in th"],"journal":["Nature materials"],"pubmed_title":["IL-12-releasing nanoparticles for effective immunotherapy of metastatic ovarian cancer."],"pmcid":["PMC12867765"],"funding_grant_id":["F99CA274651","R01CA235375","F99 CA274651","P30 CA014051","R01 CA235375"],"pubmed_authors":["Nombera Bueno E","Irvine DJ","Gomerdinger VF","Melo MB","Covarrubias G","Suh H","Pickering AJ","Billingsley MM","Backlund C","Shanker A","Wu S","Gordon E","Pires IS","Hammond PT","Pryor M"],"additional_accession":[]},"is_claimable":false,"name":"IL-12-releasing nanoparticles for effective immunotherapy of metastatic ovarian cancer.","description":"Immunotherapies such as immune checkpoint inhibitors are effective in treating several advanced cancers, but these treatments have had limited success in metastatic ovarian cancer. Here we engineered liposomal nanoparticles carrying a poly-ʟ-arginine/poly-ʟ-glutamate coating that promotes their binding and retention on the surface of ovarian cancer cells. Covalent anchoring of the potent immunostimulatory cytokine interleukin-12 (IL-12) to phospholipid headgroups of the liposome core enabled the polymer-coated particles to concentrate IL-12 in disseminated ovarian cancer tumours following intraperitoneal administration. Shedding of the layer-by-layer coating and serum-protein-mediated extraction of IL-12-conjugated lipids from the liposomal core over time enabled IL-12 to disseminate in th","dates":{"release":"2026-01-01T00:00:00Z","publication":"2026 Feb","modification":"2026-07-15T13:23:02.29Z","creation":"2026-07-05T03:08:32.51Z"},"accession":"S-EPMC12867765","cross_references":{"pubmed":["41174039"],"doi":["10.1038/s41563-025-02390-9"]}}