{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["9(1)"],"submitter":["Liu Q"],"pubmed_abstract":["Lupus nephritis (LN), the most severe complication of systemic lupus erythematosus (SLE), arises from systemic immune dysregulation and renal damage. While renal immune perturbations are well-studied, systemic signatures specific to LN pathogenesis remain unclear. Integrated single-cell RNA and immune repertoire analysis of 177,259 peripheral blood mononuclear cells (PBMCs) from healthy donors and SLE patients (including active LN and non-nephritis controls) revealed LN-specific circulating immune signatures, including κ light-chain preference in naive B cells and distinct clonal expansion in CD8<sup>+</sup> effector T cells. These clonally expanded CD8<sup>+</sup> effector T cells exhibited transcriptional variations indicating increased migratory capacity and exhaustion, along with prefe"],"journal":["Communications biology"],"pagination":["155"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12868680"],"repository":["biostudies-literature"],"pubmed_title":["Single-cell profiling unveils nephritis-related circulating immunological signatures in systemic lupus erythematosus patients."],"pmcid":["PMC12868680"],"pubmed_authors":["Zheng Y","Wu L","Yang L","Zhang J","Xie X","Liu Q","Li P","Li Q","Zhou Y","Hao S","Bai X","Cai G","Liu X","Cheng T","Lin H","Wang X","Guo C","Chen X","Deng Y","Shang S"],"additional_accession":[]},"is_claimable":false,"name":"Single-cell profiling unveils nephritis-related circulating immunological signatures in systemic lupus erythematosus patients.","description":"Lupus nephritis (LN), the most severe complication of systemic lupus erythematosus (SLE), arises from systemic immune dysregulation and renal damage. While renal immune perturbations are well-studied, systemic signatures specific to LN pathogenesis remain unclear. Integrated single-cell RNA and immune repertoire analysis of 177,259 peripheral blood mononuclear cells (PBMCs) from healthy donors and SLE patients (including active LN and non-nephritis controls) revealed LN-specific circulating immune signatures, including κ light-chain preference in naive B cells and distinct clonal expansion in CD8<sup>+</sup> effector T cells. These clonally expanded CD8<sup>+</sup> effector T cells exhibited transcriptional variations indicating increased migratory capacity and exhaustion, along with prefe","dates":{"release":"2026-01-01T00:00:00Z","publication":"2026 Jan","modification":"2026-07-15T06:07:51.282Z","creation":"2026-07-01T03:07:45.47Z"},"accession":"S-EPMC12868680","cross_references":{"pubmed":["41490945"],"doi":["10.1038/s42003-025-09431-8"]}}