{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["299(3)"],"submitter":["Billotte M"],"pubmed_abstract":["<h4>Objectives</h4>To assess factors associated with rapidly progressive interstitial lung disease (ILD) (RP-ILD) at time of ILD diagnosis in a multicentric retrospective cohort study of antisynthetase syndrome (ASyS). We used a complementary unsupervised approach, hierarchical clustering, to delineate distinct phenotypes among ASyS patients with ILD.<h4>Methods</h4>A total of 132 patients with ASyS, defined according to the 2024 ACR/European Alliance of Associations for Rheumatology (EULAR) ASyS classification criteria, and ILD, diagnosed by CT scan, were included. RP-ILD was defined by the presence of respiratory failure at ILD diagnosis or rapid ILD progression during the first 3 months.<h4>Results</h4>In our study, 39% of patients had RP-ILD at ILD diagnosis. Multivariate logistic regr"],"journal":["Journal of internal medicine"],"pagination":["365-380"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12869006"],"repository":["biostudies-literature"],"pubmed_title":["Clinical profiles associated with rapidly progressive interstitial lung disease in antisynthetase syndrome: A multicentric cohort study (TYPASS study)."],"pmcid":["PMC12869006"],"pubmed_authors":["Bonniaud P","Chaudier A","Dury S","Bolko L","Billotte M","Bonnotte B","Campagne J","Jaussaud R","Decker P","Beltramo G","Valentin S","Didier K","Moulinet T","Magy-Bertrand N","Meyer A","Camara H","Devilliers H"],"additional_accession":[]},"is_claimable":false,"name":"Clinical profiles associated with rapidly progressive interstitial lung disease in antisynthetase syndrome: A multicentric cohort study (TYPASS study).","description":"<h4>Objectives</h4>To assess factors associated with rapidly progressive interstitial lung disease (ILD) (RP-ILD) at time of ILD diagnosis in a multicentric retrospective cohort study of antisynthetase syndrome (ASyS). We used a complementary unsupervised approach, hierarchical clustering, to delineate distinct phenotypes among ASyS patients with ILD.<h4>Methods</h4>A total of 132 patients with ASyS, defined according to the 2024 ACR/European Alliance of Associations for Rheumatology (EULAR) ASyS classification criteria, and ILD, diagnosed by CT scan, were included. RP-ILD was defined by the presence of respiratory failure at ILD diagnosis or rapid ILD progression during the first 3 months.<h4>Results</h4>In our study, 39% of patients had RP-ILD at ILD diagnosis. Multivariate logistic regr","dates":{"release":"2026-01-01T00:00:00Z","publication":"2026 Mar","modification":"2026-07-15T13:30:35.346Z","creation":"2026-07-05T03:08:21.062Z"},"accession":"S-EPMC12869006","cross_references":{"pubmed":["41376133"],"doi":["10.1111/joim.70058"]}}