biostudies-literatureUnknown299(3)Billotte M<h4>Objectives</h4>To assess factors associated with rapidly progressive interstitial lung disease (ILD) (RP-ILD) at time of ILD diagnosis in a multicentric retrospective cohort study of antisynthetase syndrome (ASyS). We used a complementary unsupervised approach, hierarchical clustering, to delineate distinct phenotypes among ASyS patients with ILD.<h4>Methods</h4>A total of 132 patients with ASyS, defined according to the 2024 ACR/European Alliance of Associations for Rheumatology (EULAR) ASyS classification criteria, and ILD, diagnosed by CT scan, were included. RP-ILD was defined by the presence of respiratory failure at ILD diagnosis or rapid ILD progression during the first 3 months.<h4>Results</h4>In our study, 39% of patients had RP-ILD at ILD diagnosis. Multivariate logistic regrJournal of internal medicine365-380https://www.ebi.ac.uk/biostudies/studies/S-EPMC12869006biostudies-literatureClinical profiles associated with rapidly progressive interstitial lung disease in antisynthetase syndrome: A multicentric cohort study (TYPASS study).PMC12869006Bonniaud PChaudier ADury SBolko LBillotte MBonnotte BCampagne JJaussaud RDecker PBeltramo GValentin SDidier KMoulinet TMagy-Bertrand NMeyer ACamara HDevilliers HfalseClinical profiles associated with rapidly progressive interstitial lung disease in antisynthetase syndrome: A multicentric cohort study (TYPASS study).<h4>Objectives</h4>To assess factors associated with rapidly progressive interstitial lung disease (ILD) (RP-ILD) at time of ILD diagnosis in a multicentric retrospective cohort study of antisynthetase syndrome (ASyS). We used a complementary unsupervised approach, hierarchical clustering, to delineate distinct phenotypes among ASyS patients with ILD.<h4>Methods</h4>A total of 132 patients with ASyS, defined according to the 2024 ACR/European Alliance of Associations for Rheumatology (EULAR) ASyS classification criteria, and ILD, diagnosed by CT scan, were included. RP-ILD was defined by the presence of respiratory failure at ILD diagnosis or rapid ILD progression during the first 3 months.<h4>Results</h4>In our study, 39% of patients had RP-ILD at ILD diagnosis. Multivariate logistic regr2026-01-01T00:00:00Z2026 Mar2026-07-15T13:30:35.346Z2026-07-05T03:08:21.062ZS-EPMC128690064137613310.1111/joim.70058