{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Glans I"],"funding":["GHR Foundation","Vetenskapsrådet","Knut and Alice Wallenberg Foundation","Cure Alzheimer&amp;apos;s Fund","Stiftelsen Bundy Academy","Konung Gustaf V:s och Drottning Victorias Frimurarestiftelse","Skåne University Hospital Lund","GE Healthcare","Greta och Johan Kocks stiftelser","National Institute on Aging","Parkinsonfonden","Michael J Fox Foundation for Parkinson&amp;apos;s Research","Roche","European Research Council","Hjärnfonden","Alzheimer&amp;apos;s Association","Alzheimerfonden","Lunds Universitet"],"pagination":["100448"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12869030"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["13(2)"],"pubmed_abstract":["<h4>Background</h4>The global prevalence of dementia is rapidly expanding and is expected to triple by 2050. Approximately 45 % of dementia cases are estimated to be attributable to potentially modifiable risk factors. Identifying how these factors contribute to specific brain pathologies may improve strategies to reduce dementia incidence.<h4>Objectives, design, setting</h4>The aim of this study was to identify both non-modifiable and modifiable risk factors associated with longitudinal changes in white matter hyperintensities (WMH), amyloid-beta (Aβ) and tau. Data were acquired in the prospective observational Swedish BioFINDER-2 study between May 2017-January 2025. All participants underwent clinical assessments, questionnaires and at least two magnetic resonance imaging (MRI), Aβ Posit"],"journal":["The journal of prevention of Alzheimer's disease"],"pubmed_title":["Associations of modifiable and non-modifiable risk factors with longitudinal white matter hyperintensities, amyloid-β and tau - a prospective cohort study."],"pmcid":["PMC12869030"],"funding_grant_id":["AF-1,011799","2020-O000028","SG-23\\u20131,061717","WASP/DDLS22\\u2013066","ERAPERMED2021\\u2013184","2018-02052","AF-980907","2021-00905","101096455","2017-0383","FO2021\\u20130293","ZEN24\\u20131,069572","AF-981132","MJFF-025507","2022-00775","AF-968598","FO2022\\u20130204","2017-01541","ADG- 101096455","FO2023\\u20130163","ALZSI-26\\u20131,523522","FO2024\\u20130284","2021-02219","FO2025\\u20130055","AF-1,011949","1280/20","1412/22","2022-0231"],"pubmed_authors":["Strandberg O","Palmqvist S","Hansson O","van Westen D","Glans I","Mattsson-Carlgren N","Spotorno N","Stomrud E","Ossenkoppele R"],"additional_accession":[]},"is_claimable":false,"name":"Associations of modifiable and non-modifiable risk factors with longitudinal white matter hyperintensities, amyloid-β and tau - a prospective cohort study.","description":"<h4>Background</h4>The global prevalence of dementia is rapidly expanding and is expected to triple by 2050. Approximately 45 % of dementia cases are estimated to be attributable to potentially modifiable risk factors. Identifying how these factors contribute to specific brain pathologies may improve strategies to reduce dementia incidence.<h4>Objectives, design, setting</h4>The aim of this study was to identify both non-modifiable and modifiable risk factors associated with longitudinal changes in white matter hyperintensities (WMH), amyloid-beta (Aβ) and tau. Data were acquired in the prospective observational Swedish BioFINDER-2 study between May 2017-January 2025. All participants underwent clinical assessments, questionnaires and at least two magnetic resonance imaging (MRI), Aβ Posit","dates":{"release":"2026-01-01T00:00:00Z","publication":"2026 Feb","modification":"2026-07-15T13:18:02.236Z","creation":"2026-07-05T03:08:27.702Z"},"accession":"S-EPMC12869030","cross_references":{"pubmed":["41478835"],"doi":["10.1016/j.tjpad.2025.100448"]}}