biostudies-literatureGlans IGHR FoundationVetenskapsrådetKnut and Alice Wallenberg FoundationCure Alzheimer&amp;apos;s FundStiftelsen Bundy AcademyKonung Gustaf V:s och Drottning Victorias FrimurarestiftelseSkåne University Hospital LundGE HealthcareGreta och Johan Kocks stiftelserNational Institute on AgingParkinsonfondenMichael J Fox Foundation for Parkinson&amp;apos;s ResearchRocheEuropean Research CouncilHjärnfondenAlzheimer&amp;apos;s AssociationAlzheimerfondenLunds Universitet100448https://www.ebi.ac.uk/biostudies/studies/S-EPMC12869030biostudies-literatureUnknown13(2)<h4>Background</h4>The global prevalence of dementia is rapidly expanding and is expected to triple by 2050. Approximately 45 % of dementia cases are estimated to be attributable to potentially modifiable risk factors. Identifying how these factors contribute to specific brain pathologies may improve strategies to reduce dementia incidence.<h4>Objectives, design, setting</h4>The aim of this study was to identify both non-modifiable and modifiable risk factors associated with longitudinal changes in white matter hyperintensities (WMH), amyloid-beta (Aβ) and tau. Data were acquired in the prospective observational Swedish BioFINDER-2 study between May 2017-January 2025. All participants underwent clinical assessments, questionnaires and at least two magnetic resonance imaging (MRI), Aβ PositThe journal of prevention of Alzheimer's diseaseAssociations of modifiable and non-modifiable risk factors with longitudinal white matter hyperintensities, amyloid-β and tau - a prospective cohort study.PMC12869030AF-1,0117992020-O000028SG-23\u20131,061717WASP/DDLS22\u2013066ERAPERMED2021\u20131842018-02052AF-9809072021-009051010964552017-0383FO2021\u20130293ZEN24\u20131,069572AF-981132MJFF-0255072022-00775AF-968598FO2022\u201302042017-01541ADG- 101096455FO2023\u20130163ALZSI-26\u20131,523522FO2024\u201302842021-02219FO2025\u20130055AF-1,0119491280/201412/222022-0231Strandberg OPalmqvist SHansson Ovan Westen DGlans IMattsson-Carlgren NSpotorno NStomrud EOssenkoppele RfalseAssociations of modifiable and non-modifiable risk factors with longitudinal white matter hyperintensities, amyloid-β and tau - a prospective cohort study.<h4>Background</h4>The global prevalence of dementia is rapidly expanding and is expected to triple by 2050. Approximately 45 % of dementia cases are estimated to be attributable to potentially modifiable risk factors. Identifying how these factors contribute to specific brain pathologies may improve strategies to reduce dementia incidence.<h4>Objectives, design, setting</h4>The aim of this study was to identify both non-modifiable and modifiable risk factors associated with longitudinal changes in white matter hyperintensities (WMH), amyloid-beta (Aβ) and tau. Data were acquired in the prospective observational Swedish BioFINDER-2 study between May 2017-January 2025. All participants underwent clinical assessments, questionnaires and at least two magnetic resonance imaging (MRI), Aβ Posit2026-01-01T00:00:00Z2026 Feb2026-07-15T13:18:02.236Z2026-07-05T03:08:27.702ZS-EPMC128690304147883510.1016/j.tjpad.2025.100448