{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Tao M"],"funding":["Hubei Province Natural Science Foundation","National Natural Science Foundation of China"],"pagination":["593-608"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12869262"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["80"],"pubmed_abstract":["<h4>Introduction</h4>Abnormalities in inflammation resolution function are intimately linked to chronic inflammation, and proresolution therapies may offer novel opportunities for IBD treatment. Developmental endothelial locus 1 (DEL-1), a natural modulator of tissue immunity and inflammation resolution, has not been studied in IBD.<h4>Objectives</h4>We aimed to investigate the expression and functions of DEL-1 in IBD.<h4>Methods</h4>Assessment of DEL-1 expression in patients, murine models, and cellular levels. To explore the effects of DEL-1 in the acute and recovery phases of inflammation, overexpression plasmids, adeno-associated viruses for DEL-1 knockdown, and DEL-1-Fc fusion proteins were administered to cells and mice. Additionally, the potential mechanism of DEL-1 in IBD was demon"],"journal":["Journal of advanced research"],"pubmed_title":["Developmentally endothelial locus-1 facilitates intestinal inflammation resolution by suppressing the Cmpk2-cGAS-STING pathway and promoting reparatory macrophage transition."],"pmcid":["PMC12869262"],"funding_grant_id":["82270559","82273321","81770554","81974383","2023AFD044","82070572"],"pubmed_authors":["Tao M","Tang M","Lin R","Zhang J","Chen J","Fu Y","Chen C","Wang Y","Yan W","Wang L","Zhao X","Feng Q"],"additional_accession":[]},"is_claimable":false,"name":"Developmentally endothelial locus-1 facilitates intestinal inflammation resolution by suppressing the Cmpk2-cGAS-STING pathway and promoting reparatory macrophage transition.","description":"<h4>Introduction</h4>Abnormalities in inflammation resolution function are intimately linked to chronic inflammation, and proresolution therapies may offer novel opportunities for IBD treatment. Developmental endothelial locus 1 (DEL-1), a natural modulator of tissue immunity and inflammation resolution, has not been studied in IBD.<h4>Objectives</h4>We aimed to investigate the expression and functions of DEL-1 in IBD.<h4>Methods</h4>Assessment of DEL-1 expression in patients, murine models, and cellular levels. To explore the effects of DEL-1 in the acute and recovery phases of inflammation, overexpression plasmids, adeno-associated viruses for DEL-1 knockdown, and DEL-1-Fc fusion proteins were administered to cells and mice. Additionally, the potential mechanism of DEL-1 in IBD was demon","dates":{"release":"2026-01-01T00:00:00Z","publication":"2026 Feb","modification":"2026-07-15T12:08:12.951Z","creation":"2026-07-04T03:12:44.859Z"},"accession":"S-EPMC12869262","cross_references":{"pubmed":["40288675"],"doi":["10.1016/j.jare.2025.04.030"]}}