biostudies-literatureTao MHubei Province Natural Science FoundationNational Natural Science Foundation of China593-608https://www.ebi.ac.uk/biostudies/studies/S-EPMC12869262biostudies-literatureUnknown80<h4>Introduction</h4>Abnormalities in inflammation resolution function are intimately linked to chronic inflammation, and proresolution therapies may offer novel opportunities for IBD treatment. Developmental endothelial locus 1 (DEL-1), a natural modulator of tissue immunity and inflammation resolution, has not been studied in IBD.<h4>Objectives</h4>We aimed to investigate the expression and functions of DEL-1 in IBD.<h4>Methods</h4>Assessment of DEL-1 expression in patients, murine models, and cellular levels. To explore the effects of DEL-1 in the acute and recovery phases of inflammation, overexpression plasmids, adeno-associated viruses for DEL-1 knockdown, and DEL-1-Fc fusion proteins were administered to cells and mice. Additionally, the potential mechanism of DEL-1 in IBD was demonJournal of advanced researchDevelopmentally endothelial locus-1 facilitates intestinal inflammation resolution by suppressing the Cmpk2-cGAS-STING pathway and promoting reparatory macrophage transition.PMC12869262822705598227332181770554819743832023AFD04482070572Tao MTang MLin RZhang JChen JFu YChen CWang YYan WWang LZhao XFeng QfalseDevelopmentally endothelial locus-1 facilitates intestinal inflammation resolution by suppressing the Cmpk2-cGAS-STING pathway and promoting reparatory macrophage transition.<h4>Introduction</h4>Abnormalities in inflammation resolution function are intimately linked to chronic inflammation, and proresolution therapies may offer novel opportunities for IBD treatment. Developmental endothelial locus 1 (DEL-1), a natural modulator of tissue immunity and inflammation resolution, has not been studied in IBD.<h4>Objectives</h4>We aimed to investigate the expression and functions of DEL-1 in IBD.<h4>Methods</h4>Assessment of DEL-1 expression in patients, murine models, and cellular levels. To explore the effects of DEL-1 in the acute and recovery phases of inflammation, overexpression plasmids, adeno-associated viruses for DEL-1 knockdown, and DEL-1-Fc fusion proteins were administered to cells and mice. Additionally, the potential mechanism of DEL-1 in IBD was demon2026-01-01T00:00:00Z2026 Feb2026-07-15T12:08:12.951Z2026-07-04T03:12:44.859ZS-EPMC128692624028867510.1016/j.jare.2025.04.030