{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Xie X"],"funding":["Intramural NIH HHS","National Institute of Allergy and Infectious Diseases Division of Intramural Research","National Institutes of Health"],"pagination":["116838"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12869356"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["45(1)"],"pubmed_abstract":["Eos, a member of the Ikaros family of transcription factors, is expressed by T regulatory cells (Tregs) and has been postulated to play a role in Treg suppression and maintenance of Treg stability. We demonstrate that expression of Eos was limited to a subpopulation of thymus-derived, activated Tregs and is undetectable in resting or activated T conventional cells. Eos associates with Helios and Foxp3 and binds directly to the CD25 locus at a site identical to the Foxp3-binding site, thereby enhancing CD25 expression. Studies in heterozygous female mice demonstrate that Eos is critical for Treg survival and activation. Eos<sup>+</sup> Tregs also represent the major population of recirculating thymic Tregs, in which Eos plays a critical role in regulating their migration and suppression of "],"journal":["Cell reports"],"pubmed_title":["Eos plays a critical role in Treg homeostasis and modulates the function of recirculating thymic Tregs in the control of Treg development."],"pmcid":["PMC12869356"],"funding_grant_id":["AI000959-20","Z01 AI000959"],"pubmed_authors":["Hill T","Veres T","Markowitz TE","Shamsaddini A","Kabat J","Lin CC","Smelkinson M","Otaizo-Carrasquero F","Wells AC","Gardina P","Shevach EM","Cho K","Rivera CA","Chen X","Segrist E","Wu Y","Xie X","Wei D","Teijeiro A","Khleborodova A","Schwartz OM","Thornton AM","Khillan JS","Tanwar S","Zhu J","Martens C","Levin Y","Korty P"],"additional_accession":[]},"is_claimable":false,"name":"Eos plays a critical role in Treg homeostasis and modulates the function of recirculating thymic Tregs in the control of Treg development.","description":"Eos, a member of the Ikaros family of transcription factors, is expressed by T regulatory cells (Tregs) and has been postulated to play a role in Treg suppression and maintenance of Treg stability. We demonstrate that expression of Eos was limited to a subpopulation of thymus-derived, activated Tregs and is undetectable in resting or activated T conventional cells. Eos associates with Helios and Foxp3 and binds directly to the CD25 locus at a site identical to the Foxp3-binding site, thereby enhancing CD25 expression. Studies in heterozygous female mice demonstrate that Eos is critical for Treg survival and activation. Eos<sup>+</sup> Tregs also represent the major population of recirculating thymic Tregs, in which Eos plays a critical role in regulating their migration and suppression of ","dates":{"release":"2026-01-01T00:00:00Z","publication":"2026 Jan","modification":"2026-07-15T12:06:20.608Z","creation":"2026-07-04T03:12:06.801Z"},"accession":"S-EPMC12869356","cross_references":{"pubmed":["41474621"],"doi":["10.1016/j.celrep.2025.116838"]}}