{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"submitter":["Westlin C"],"pubmed_abstract":["<h4>Background</h4>Clinical trajectories in functional neurological disorder (FND) are variable, and the mechanisms underlying this heterogeneity remain poorly understood.<h4>Objective</h4>This longitudinal study examined resting-state functional connectivity predictors and mechanisms of symptom change in FND.<h4>Methods</h4>Thirty-two adults with FND (motor and/or seizure phenotypes) completed baseline questionnaires and a functional MRI (fMRI) session, followed by naturalistic treatment for 6.8±0.8 months. All participants completed follow-up questionnaires; 28 individuals completed a follow-up fMRI. At each timepoint, three graph-theory network metrics of functional connectivity were computed: weighted-degree (centrality), integration (<i>between-network</i> connectivity), and segregati"],"journal":["medRxiv : the preprint server for health sciences"],"pagination":["2026.01.27.26344860"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12870675"],"repository":["biostudies-literature"],"pubmed_title":["Functional Connectivity Predictors and Mechanisms of Symptom Change in Functional Neurological Disorder."],"pmcid":["PMC12870675"],"pubmed_authors":["Stephen CD","Bleier C","MacLean J","Diez I","Adams C","Guthrie AJ","Ranford J","Godena E","Maggio J","Perez DL","Millstein D","Finkelstein SA","Freeburn J","Westlin C"],"additional_accession":[]},"is_claimable":false,"name":"Functional Connectivity Predictors and Mechanisms of Symptom Change in Functional Neurological Disorder.","description":"<h4>Background</h4>Clinical trajectories in functional neurological disorder (FND) are variable, and the mechanisms underlying this heterogeneity remain poorly understood.<h4>Objective</h4>This longitudinal study examined resting-state functional connectivity predictors and mechanisms of symptom change in FND.<h4>Methods</h4>Thirty-two adults with FND (motor and/or seizure phenotypes) completed baseline questionnaires and a functional MRI (fMRI) session, followed by naturalistic treatment for 6.8±0.8 months. All participants completed follow-up questionnaires; 28 individuals completed a follow-up fMRI. At each timepoint, three graph-theory network metrics of functional connectivity were computed: weighted-degree (centrality), integration (<i>between-network</i> connectivity), and segregati","dates":{"release":"2026-01-01T00:00:00Z","publication":"2026 Jan","modification":"2026-07-09T13:11:54.49Z","creation":"2026-07-09T13:09:44.799Z"},"accession":"S-EPMC12870675","cross_references":{"pubmed":["41646801"],"doi":["10.64898/2026.01.27.26344860"]}}