biostudies-literatureUnknownWestlin C<h4>Background</h4>Clinical trajectories in functional neurological disorder (FND) are variable, and the mechanisms underlying this heterogeneity remain poorly understood.<h4>Objective</h4>This longitudinal study examined resting-state functional connectivity predictors and mechanisms of symptom change in FND.<h4>Methods</h4>Thirty-two adults with FND (motor and/or seizure phenotypes) completed baseline questionnaires and a functional MRI (fMRI) session, followed by naturalistic treatment for 6.8±0.8 months. All participants completed follow-up questionnaires; 28 individuals completed a follow-up fMRI. At each timepoint, three graph-theory network metrics of functional connectivity were computed: weighted-degree (centrality), integration (<i>between-network</i> connectivity), and segregatimedRxiv : the preprint server for health sciences2026.01.27.26344860https://www.ebi.ac.uk/biostudies/studies/S-EPMC12870675biostudies-literatureFunctional Connectivity Predictors and Mechanisms of Symptom Change in Functional Neurological Disorder.PMC12870675Stephen CDBleier CMacLean JDiez IAdams CGuthrie AJRanford JGodena EMaggio JPerez DLMillstein DFinkelstein SAFreeburn JWestlin CfalseFunctional Connectivity Predictors and Mechanisms of Symptom Change in Functional Neurological Disorder.<h4>Background</h4>Clinical trajectories in functional neurological disorder (FND) are variable, and the mechanisms underlying this heterogeneity remain poorly understood.<h4>Objective</h4>This longitudinal study examined resting-state functional connectivity predictors and mechanisms of symptom change in FND.<h4>Methods</h4>Thirty-two adults with FND (motor and/or seizure phenotypes) completed baseline questionnaires and a functional MRI (fMRI) session, followed by naturalistic treatment for 6.8±0.8 months. All participants completed follow-up questionnaires; 28 individuals completed a follow-up fMRI. At each timepoint, three graph-theory network metrics of functional connectivity were computed: weighted-degree (centrality), integration (<i>between-network</i> connectivity), and segregati2026-01-01T00:00:00Z2026 Jan2026-07-09T13:11:54.49Z2026-07-09T13:09:44.799ZS-EPMC128706754164680110.64898/2026.01.27.26344860