{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"submitter":["Cassidy AC"],"funding":["NEI NIH HHS","NIDDK NIH HHS","NCI NIH HHS","NIGMS NIH HHS"],"pubmed_abstract":["Microtubule dynamics change during cell division to enable rapid microtubule network remodeling. The switching from microtubule growth to shrinkage is attributed to the loss of a stabilizing GTP-cap structure at the growing microtubule end. The size of the GTP-cap is a result of a balance between GTP-tubulin addition to the microtubule end and subsequent GTP-hydrolysis in the microtubule lattice. Whether the cell-cycle-dependent changes in microtubule dynamics are supported by concurrent modulation of the stabilizing GTP-cap size is not known. Here, we use high spatiotemporal resolution live-cell imaging of EB1, an established marker for the GTP-cap, to directly determine the relationship between GTP-cap size and microtubule growth rate throughout the cell cycle. Our data reveal that GTP-c"],"journal":["bioRxiv : the preprint server for biology"],"pagination":["2026.01.13.699367"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12871301"],"repository":["biostudies-literature"],"pubmed_title":["The microtubule GTP-tubulin cap size is modulated during cell division."],"pmcid":["PMC12871301"],"funding_grant_id":["P30 CA068485","R35 GM125028","P30 DK058404","P30 EY008126","R35 GM119552"],"pubmed_authors":["Zanic M","Burnette DT","Cassidy AC"],"additional_accession":[]},"is_claimable":false,"name":"The microtubule GTP-tubulin cap size is modulated during cell division.","description":"Microtubule dynamics change during cell division to enable rapid microtubule network remodeling. The switching from microtubule growth to shrinkage is attributed to the loss of a stabilizing GTP-cap structure at the growing microtubule end. The size of the GTP-cap is a result of a balance between GTP-tubulin addition to the microtubule end and subsequent GTP-hydrolysis in the microtubule lattice. Whether the cell-cycle-dependent changes in microtubule dynamics are supported by concurrent modulation of the stabilizing GTP-cap size is not known. Here, we use high spatiotemporal resolution live-cell imaging of EB1, an established marker for the GTP-cap, to directly determine the relationship between GTP-cap size and microtubule growth rate throughout the cell cycle. Our data reveal that GTP-c","dates":{"release":"2026-01-01T00:00:00Z","publication":"2026 Jan","modification":"2026-07-06T03:17:58.423Z","creation":"2026-07-06T03:11:41.171Z"},"accession":"S-EPMC12871301","cross_references":{"pubmed":["41648122"],"doi":["10.64898/2026.01.13.699367"]}}