{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Hayden CMT"],"funding":["UC Davis T32 in Pharmacology","NIDDK NIH HHS","Paul F. Gulyassy Endowment","National Institute of Diabetes and Digestive and Kidney Diseases U2C/TL1 LAUNCH program","Peretz Family Fund for Connective Tissue Research","NIGMS NIH HHS"],"pagination":["1113-1136"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12871929"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["604(3)"],"pubmed_abstract":["Spontaneous tendon rupture occurs in a concerning number of individuals with chronic kidney disease (CKD); however almost no data exist regarding CKD-related tendon pathology. Given that tendon ruptures have a significant impact on health and well-being we sought to determine whether tendon mechanics are altered by kidney disease in an established rat model of CKD. Male and female Sprague-Dawley rats (age = 8 weeks) were equally divided into a control group (CON, n = 16) and a group fed a diet containing 0.25% adenine to induce kidney disease (<sub>ADI</sub>CKD). After 9 weeks, Achilles and tibialis anterior (TA) tendons were excised, and maximum tensile load (MTL), failure stress, modulus and cross-sectional area (CSA) were measured and evaluated by two-way ANOVA (main effects: CKD and se"],"journal":["The Journal of physiology"],"pubmed_title":["Kidney disease impairs tendon function in rats."],"pmcid":["PMC12871929"],"funding_grant_id":["N/A","T32 GM144303","GM144303","TL1 DK139565","DK139565"],"pubmed_authors":["Osipov B","Jen KY","Gilmore NK","Smith LR","Christiansen BA","Hayden CMT","Brashear SE","Gorge M","Roshanravan B","Baar K"],"additional_accession":[]},"is_claimable":false,"name":"Kidney disease impairs tendon function in rats.","description":"Spontaneous tendon rupture occurs in a concerning number of individuals with chronic kidney disease (CKD); however almost no data exist regarding CKD-related tendon pathology. Given that tendon ruptures have a significant impact on health and well-being we sought to determine whether tendon mechanics are altered by kidney disease in an established rat model of CKD. Male and female Sprague-Dawley rats (age = 8 weeks) were equally divided into a control group (CON, n = 16) and a group fed a diet containing 0.25% adenine to induce kidney disease (<sub>ADI</sub>CKD). After 9 weeks, Achilles and tibialis anterior (TA) tendons were excised, and maximum tensile load (MTL), failure stress, modulus and cross-sectional area (CSA) were measured and evaluated by two-way ANOVA (main effects: CKD and se","dates":{"release":"2026-01-01T00:00:00Z","publication":"2026 Feb","modification":"2026-07-16T09:39:54.504Z","creation":"2026-07-09T10:47:00.718Z"},"accession":"S-EPMC12871929","cross_references":{"pubmed":["41474384"],"doi":["10.1113/JP289753"]}}