biostudies-literatureKunzel SHNEI NIH HHSNational Eye InstituteDFGResearch to Prevent BlindnessUniversity of BonnNational Institutes of Health794-803https://www.ebi.ac.uk/biostudies/studies/S-EPMC12872259biostudies-literatureUnknown8(8)<h4>Objective</h4>The primary goal of this study was to determine how structural and functional parameters influence the vision-related quality of life (VRQoL) in patients suffering from geographic atrophy (GA) secondary to age-related macular degeneration.<h4>Design</h4>This study was designed as a prospective, noninterventional, natural-history study (Directional Spread in Geographic-Atrophy study, NCT02051998).<h4>Subjects</h4>The research involved 82 patients with bilateral GA.<h4>Methods</h4>The study examined parameters including GA location as assessed by the ETDRS grid, best-corrected visual acuity, low-luminance visual acuity (LLVA), reading acuity, and speed. These parameters were then correlated with VRQoL, which was gauged using the National Eye Institute Visual Function QuestiOphthalmology. RetinaAssociation of Lesion Location and Functional Parameters with Vision-Related Quality of Life in Geographic Atrophy Secondary to Age-related Macular Degeneration.PMC12872259R01 EY034965P30 EY014800R01 EY033365Fleckenstein MMoller PTSchmitz-Valckenberg SBroadbent EGoerdt LCzauderna JHolz FGLindner MPfau MKunzel SHfalseAssociation of Lesion Location and Functional Parameters with Vision-Related Quality of Life in Geographic Atrophy Secondary to Age-related Macular Degeneration.<h4>Objective</h4>The primary goal of this study was to determine how structural and functional parameters influence the vision-related quality of life (VRQoL) in patients suffering from geographic atrophy (GA) secondary to age-related macular degeneration.<h4>Design</h4>This study was designed as a prospective, noninterventional, natural-history study (Directional Spread in Geographic-Atrophy study, NCT02051998).<h4>Subjects</h4>The research involved 82 patients with bilateral GA.<h4>Methods</h4>The study examined parameters including GA location as assessed by the ETDRS grid, best-corrected visual acuity, low-luminance visual acuity (LLVA), reading acuity, and speed. These parameters were then correlated with VRQoL, which was gauged using the National Eye Institute Visual Function Questi2024-01-01T00:00:00Z2024 Aug2026-07-05T03:11:02.261Z2026-07-05T03:08:19.035ZS-EPMC128722593831120710.1016/j.oret.2024.01.025