{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["16"],"submitter":["Hancock M"],"pubmed_abstract":["<h4>Context</h4>Thyroid hormones affect neurological development and function, but detailed studies of thyroid hormones and metabolites in autism are lacking.<h4>Objective</h4>To characterize thyroid function and metabolism in autistic children.<h4>Methodology</h4>This cross-sectional study compared 788 autistic children (mean age 7.6 ± 3.9 years, 78% male) with 301 non-autistic children (mean age 7.8 ± 4.0 years, 48% male; comprising 215 (71.4%) non-autistic siblings of participants and 86 (28.6%) unrelated individuals). Plasma TSH, free T4 (FT4) and free T3 (FT3) were measured by automated immunoassay, and total T4, total T3 and thyroid hormone metabolites by customized liquid chromatography-tandem mass spectrometry (LCMS/MS). Regression analyses were adjusted for age and sex.<h4>Results"],"journal":["Frontiers in endocrinology"],"pagination":["1716586"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12872564"],"repository":["biostudies-literature"],"pubmed_title":["Circulating thyroid hormones and metabolites in children with autism spectrum disorder."],"pmcid":["PMC12872564"],"pubmed_authors":["Mullin S","Lim EM","Campbell PJ","Boyder C","Wilson SG","Whitehouse AJO","Brown SJ","Zhang R","Walsh JP","Hancock M"],"additional_accession":[]},"is_claimable":false,"name":"Circulating thyroid hormones and metabolites in children with autism spectrum disorder.","description":"<h4>Context</h4>Thyroid hormones affect neurological development and function, but detailed studies of thyroid hormones and metabolites in autism are lacking.<h4>Objective</h4>To characterize thyroid function and metabolism in autistic children.<h4>Methodology</h4>This cross-sectional study compared 788 autistic children (mean age 7.6 ± 3.9 years, 78% male) with 301 non-autistic children (mean age 7.8 ± 4.0 years, 48% male; comprising 215 (71.4%) non-autistic siblings of participants and 86 (28.6%) unrelated individuals). Plasma TSH, free T4 (FT4) and free T3 (FT3) were measured by automated immunoassay, and total T4, total T3 and thyroid hormone metabolites by customized liquid chromatography-tandem mass spectrometry (LCMS/MS). Regression analyses were adjusted for age and sex.<h4>Results","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025","modification":"2026-07-15T06:37:36.858Z","creation":"2026-07-02T03:08:39.445Z"},"accession":"S-EPMC12872564","cross_references":{"pubmed":["41659339"],"doi":["10.3389/fendo.2025.1716586"]}}