biostudies-literatureUnknown16Hancock M<h4>Context</h4>Thyroid hormones affect neurological development and function, but detailed studies of thyroid hormones and metabolites in autism are lacking.<h4>Objective</h4>To characterize thyroid function and metabolism in autistic children.<h4>Methodology</h4>This cross-sectional study compared 788 autistic children (mean age 7.6 ± 3.9 years, 78% male) with 301 non-autistic children (mean age 7.8 ± 4.0 years, 48% male; comprising 215 (71.4%) non-autistic siblings of participants and 86 (28.6%) unrelated individuals). Plasma TSH, free T4 (FT4) and free T3 (FT3) were measured by automated immunoassay, and total T4, total T3 and thyroid hormone metabolites by customized liquid chromatography-tandem mass spectrometry (LCMS/MS). Regression analyses were adjusted for age and sex.<h4>ResultsFrontiers in endocrinology1716586https://www.ebi.ac.uk/biostudies/studies/S-EPMC12872564biostudies-literatureCirculating thyroid hormones and metabolites in children with autism spectrum disorder.PMC12872564Mullin SLim EMCampbell PJBoyder CWilson SGWhitehouse AJOBrown SJZhang RWalsh JPHancock MfalseCirculating thyroid hormones and metabolites in children with autism spectrum disorder.<h4>Context</h4>Thyroid hormones affect neurological development and function, but detailed studies of thyroid hormones and metabolites in autism are lacking.<h4>Objective</h4>To characterize thyroid function and metabolism in autistic children.<h4>Methodology</h4>This cross-sectional study compared 788 autistic children (mean age 7.6 ± 3.9 years, 78% male) with 301 non-autistic children (mean age 7.8 ± 4.0 years, 48% male; comprising 215 (71.4%) non-autistic siblings of participants and 86 (28.6%) unrelated individuals). Plasma TSH, free T4 (FT4) and free T3 (FT3) were measured by automated immunoassay, and total T4, total T3 and thyroid hormone metabolites by customized liquid chromatography-tandem mass spectrometry (LCMS/MS). Regression analyses were adjusted for age and sex.<h4>Results2025-01-01T00:00:00Z20252026-07-15T06:37:36.858Z2026-07-02T03:08:39.445ZS-EPMC128725644165933910.3389/fendo.2025.1716586