biostudies-literatureAbdullah LCongressionally Directed Medical Research Programs4933https://www.ebi.ac.uk/biostudies/studies/S-EPMC12873323biostudies-literatureUnknown16(1)Gulf War Illness (GWI) affects 32% of Veterans from the 1990-1991 Gulf War. It is characterized by fatigue, mood disturbances, pain and cognitive decrements, with no FDA-approved treatment. This exploratory randomized, double-blind, placebo-controlled trial evaluated the safety and efficacy of oleoylethanolamide (OEA) supplementation in 52 Veterans with GWI (mean age 59 ± 5 SD, 94% males and 79% White). Participants received 200 mg of OEA twice daily or a matching placebo for 10 weeks, followed by a 5-week open-label OEA extension. Outcomes included the Multidimensional Fatigue Inventory (MFI-20), abbreviated Profile of Mood States (POMS), Short-Form McGill Pain Questionnaire, Veterans RAND 36-Item Health Survey (SF-36 V), Repeatable Battery for the Assessment of Neuropsychological Status Scientific reportsOleoylethanolamide supplementation improves mood and reduces fatigue in veterans with GWI in a 15-week randomized, double-blind, placebo-controlled exploratory clinical trial.PMC12873323GW1800045Keegan APLuis CHelgager DSullivan KCseresznye ACrawford FAbdullah LRindfleisch CMack WHoffmann MBaraniuk JMullan MHuguenard CJCAldrich GJEvans JEParis DfalseOleoylethanolamide supplementation improves mood and reduces fatigue in veterans with GWI in a 15-week randomized, double-blind, placebo-controlled exploratory clinical trial.Gulf War Illness (GWI) affects 32% of Veterans from the 1990-1991 Gulf War. It is characterized by fatigue, mood disturbances, pain and cognitive decrements, with no FDA-approved treatment. This exploratory randomized, double-blind, placebo-controlled trial evaluated the safety and efficacy of oleoylethanolamide (OEA) supplementation in 52 Veterans with GWI (mean age 59 ± 5 SD, 94% males and 79% White). Participants received 200 mg of OEA twice daily or a matching placebo for 10 weeks, followed by a 5-week open-label OEA extension. Outcomes included the Multidimensional Fatigue Inventory (MFI-20), abbreviated Profile of Mood States (POMS), Short-Form McGill Pain Questionnaire, Veterans RAND 36-Item Health Survey (SF-36 V), Repeatable Battery for the Assessment of Neuropsychological Status 2026-01-01T00:00:00Z2026 Jan2026-07-15T06:32:17.139Z2026-06-30T03:21:41.997ZS-EPMC128733234151398110.1038/s41598-026-35168-3