{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["14(2)"],"submitter":["Xiong M"],"pubmed_abstract":["<h4>Background</h4>Periodontitis, a chronic inflammatory disease, represents the primary cause of tooth loss in Chinese adults. Wilms tumor 1-associating protein (WTAP) is a key component of the N6-methyladenosine (m6A) methyltransferase complex, and has an unclear role in periodontitis pathogenesis, particularly concerning its regulatory functions in periodontal ligament stem cells (PDLSCs).<h4>Methods</h4>The target gene was identified through the GES260558 dataset and Genecards database. Gene expression was measured using reverse transcription-quantitative PCR (RT-qPCR) and western blot. Periodontitis-derived PDLSCs (P-PDLSCs) were isolated and identified by alkaline phosphatase (ALP) staining, oil red O staining, and flow cytometry. Malondialdehyde (MDA), superoxide dismutase (SOD), an"],"journal":["Immunity, inflammation and disease"],"pagination":["e70335"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12873629"],"repository":["biostudies-literature"],"pubmed_title":["WTAP Contributes to Periodontitis Pathogenesis by Promoting PDLSC Senescence and Impairing Osteogenic Differentiation via m6A-Dependent Regulation of TP53BP1."],"pmcid":["PMC12873629"],"pubmed_authors":["Liu Y","Xiong M","Wang T"],"additional_accession":[]},"is_claimable":false,"name":"WTAP Contributes to Periodontitis Pathogenesis by Promoting PDLSC Senescence and Impairing Osteogenic Differentiation via m6A-Dependent Regulation of TP53BP1.","description":"<h4>Background</h4>Periodontitis, a chronic inflammatory disease, represents the primary cause of tooth loss in Chinese adults. Wilms tumor 1-associating protein (WTAP) is a key component of the N6-methyladenosine (m6A) methyltransferase complex, and has an unclear role in periodontitis pathogenesis, particularly concerning its regulatory functions in periodontal ligament stem cells (PDLSCs).<h4>Methods</h4>The target gene was identified through the GES260558 dataset and Genecards database. Gene expression was measured using reverse transcription-quantitative PCR (RT-qPCR) and western blot. Periodontitis-derived PDLSCs (P-PDLSCs) were isolated and identified by alkaline phosphatase (ALP) staining, oil red O staining, and flow cytometry. Malondialdehyde (MDA), superoxide dismutase (SOD), an","dates":{"release":"2026-01-01T00:00:00Z","publication":"2026 Feb","modification":"2026-07-05T03:08:57.414Z","creation":"2026-07-05T03:08:02.377Z"},"accession":"S-EPMC12873629","cross_references":{"pubmed":["41641517"],"doi":["10.1002/iid3.70335"]}}