{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["25(2)"],"submitter":["Jensen PT"],"pubmed_abstract":["S-palmitoylation is a poorly understood post-translational modification that is gaining more attention as an essential regulator of cellular processes. The reversible nature of S-palmitoylation may allow for fine-tuned control of cellular events and adaptation to stimuli. The detection of S-palmitoylated proteins and peptides includes the Acyl-Biotin Exchange (ABE) method, Acyl resin-assisted Capture (Acyl-RAC), metabolic labelling, and derivatives thereof. We present a novel method of enrichment of S-palmitoylated peptides termed SDC Acid Precipitation Enrichment (SDC-ACE). Here, S-palmitoylated peptides are enriched by taking advantage of their co-precipitation with Sodium deoxycholate (SDC) under acidic conditions, allowing easy and fast separation of lipidated peptides from the sample "],"journal":["Molecular & cellular proteomics : MCP"],"pagination":["101218"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12874130"],"repository":["biostudies-literature"],"pubmed_title":["Enrichment of Cysteine S-palmitoylated Peptides Using Sodium Deoxycholate Acid Precipitation."],"pmcid":["PMC12874130"],"pubmed_authors":["Jensen PT","Rhodes CJ","Palmisano G","Larsen MR"],"additional_accession":[]},"is_claimable":false,"name":"Enrichment of Cysteine S-palmitoylated Peptides Using Sodium Deoxycholate Acid Precipitation.","description":"S-palmitoylation is a poorly understood post-translational modification that is gaining more attention as an essential regulator of cellular processes. The reversible nature of S-palmitoylation may allow for fine-tuned control of cellular events and adaptation to stimuli. The detection of S-palmitoylated proteins and peptides includes the Acyl-Biotin Exchange (ABE) method, Acyl resin-assisted Capture (Acyl-RAC), metabolic labelling, and derivatives thereof. We present a novel method of enrichment of S-palmitoylated peptides termed SDC Acid Precipitation Enrichment (SDC-ACE). Here, S-palmitoylated peptides are enriched by taking advantage of their co-precipitation with Sodium deoxycholate (SDC) under acidic conditions, allowing easy and fast separation of lipidated peptides from the sample ","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Oct","modification":"2026-07-15T06:19:01.773Z","creation":"2026-06-30T03:23:05.881Z"},"accession":"S-EPMC12874130","cross_references":{"pubmed":["41109480"],"doi":["10.1016/j.mcpro.2025.101218"]}}