{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Lee S"],"funding":["NIHR Barts Biomedical Research Centre","National Institute for Health and Care Research","National Institutes of Health","National Heart Lung and Blood Institute"],"pagination":["100566"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12874302"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["7(2)"],"pubmed_abstract":["Gene-environment interactions may enhance our understanding of blood pressure (BP) biology. We conducted a meta-analysis of multi-population genome-wide association studies (GWASs) of BP traits accounting for gene-depressive symptomatology (DEPR) interactions. Our study included 564,680 adults from 67 cohorts and four population backgrounds: African (5%), Asian (7%), European (85%), and Hispanic (3%). We discovered seven previously unreported BP loci showing gene-DEPR interaction. These loci mapped to genes implicated in neurogenesis (TGFA and CASP3), lipid metabolism (ACSL1), neuronal apoptosis (CASP3), and synaptic activity (CNTN6 and DBI). We also showed evidence for gene-DEPR interaction at nine known BP loci, further suggesting links between mood disturbance and BP regulation. Of the "],"journal":["HGG advances"],"pubmed_title":["Large-scale blood pressure GWAS accounting for gene-depression interactions in 564,680 individuals from diverse populations."],"pmcid":["PMC12874302"],"funding_grant_id":["R01HD057194","R01HL163972","R01HL142302","NIHR202330","R01HL163262","HL105756","R01HL118305","R01HG010297","R01DK117445","R01HL151152","R01HL156991","R01DK122503","R01MD012765","R01HL143885"],"pubmed_authors":["Okochi T","Psaty BM","Kardia SLR","Saito T","Lefevre C","Guo X","Conen D","Rosendaal FR","Gudnason V","Attia JR","Manning A","Shen B","Terao C","Tai ES","Morrison AC","Zhang R","Harris SE","Faquih T","Province MM","Karvonen-Gutierrez CA","Grabe HJ","Matsuda K","Taylor AM","O'Connell JR","Miller CL","Risch M","Rotimi CN","Nolte IM","Risch L","Weir DR","Shikany J","Ansari MAY","Raitakari OT","Girotto G","Spedicati B","Morrison JL","Do A","Bartz TM","Edwards TL","Redline S","Lyytikainen LP","Gudmundsdottir V","Cox SR","Scott RJ","Schwander K","Levy D","Noordam R","Ware EB","Davies G","Cade B","Santin A","Hikino K","Lee S","Russ TC","Kraja AT","Concas MP","Nagarajan P","Zhao W","Graff M","Munroe PB","Penninx BWJH","Gauderman WJ","Tang J","Brown MR","McNeil JJ","Roux AD","de Las Fuentes L","Lacaze P","Smith JA","Taylor KD","Martin LW","van Dam RM","Kho M","Milaneschi Y","Aschard H","Hood MM","Bis JC","Fohner AE","Faul JD","Huang Z","Nardone GG","Yu C","Breyer M","Fox ER","Zhu X","de Vries PS","Rotter JI","Theriault S","Young KL","Wang H","Maheshwari M","Schmidt H","Zonderman AB","Lifelines Cohort Study,","Jost JB","Gu C","Sun Q","Wang R","Schmidt R","Ruiz-Narvaez EA","Wenbin W","Xie T","Yao J","Li C","Raffield LM","Chen G","Kahonen M","Biobank Japan Project","Franceschini N","Schreiner PJ","Chen H","Gangireddy S","Anugu P","Gepner A","Tesolin P","Evans MK","Ammous F","Liu CT","Xing WY","Bazzano LA","Peyser PA","Du J","Fornage M","Giri A","Dorr M","van der Most PJ","Hofer E","Feitosa MF","Corley J","Jaquish CE","Bierut LJ","Winkler TW","Westerman K","Bentley AR","Holliday E","Sofer T","Jie X","Weiss S","Lehtimaki T","Harlow SD","Dupont CT","Homuth G","Collins S","Tan YA","Rao DC","Fretts AM","Snieder H","Sim X","Launer LJ","North KE"],"additional_accession":[]},"is_claimable":false,"name":"Large-scale blood pressure GWAS accounting for gene-depression interactions in 564,680 individuals from diverse populations.","description":"Gene-environment interactions may enhance our understanding of blood pressure (BP) biology. We conducted a meta-analysis of multi-population genome-wide association studies (GWASs) of BP traits accounting for gene-depressive symptomatology (DEPR) interactions. Our study included 564,680 adults from 67 cohorts and four population backgrounds: African (5%), Asian (7%), European (85%), and Hispanic (3%). We discovered seven previously unreported BP loci showing gene-DEPR interaction. These loci mapped to genes implicated in neurogenesis (TGFA and CASP3), lipid metabolism (ACSL1), neuronal apoptosis (CASP3), and synaptic activity (CNTN6 and DBI). We also showed evidence for gene-DEPR interaction at nine known BP loci, further suggesting links between mood disturbance and BP regulation. Of the ","dates":{"release":"2026-01-01T00:00:00Z","publication":"2026 Jan","modification":"2026-07-15T07:40:06.051Z","creation":"2026-07-01T03:07:51.823Z"},"accession":"S-EPMC12874302","cross_references":{"pubmed":["41520179"],"doi":["10.1016/j.xhgg.2026.100566"]}}