{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"submitter":["Azarbarzin A"],"funding":["ResMed Foundation","ICREA Academia program from the Generalitat de Catalunya","NHLBI NIH HHS","National Institute of Health NHLBI","ResMed Inc.","American Academy of Sleep Medicine","RICCADSA: The Swedish Research Council","AHA","NIH NHLBI","Swedish Heart-Lung Foundation"],"pubmed_abstract":["<h4>Background and aims</h4>Randomized trials of continuous positive airway pressure (CPAP) treatment for obstructive sleep apnoea (OSA) in patients with cardiovascular disease have not detected reduced risk of major adverse cardiovascular and cerebrovascular events (MACCEs). This study tested whether the cardiovascular benefit of CPAP occurs preferentially in high-risk OSA, characterized by greater OSA-related heart rate acceleration or hypoxaemia.<h4>Methods</h4>In a post hoc analysis of pooled Randomized Intervention with Continuous Positive Airway Pressure in Coronary Artery Disease and Obstructive Sleep Apnoea, Impact of Continuous Positive Airway Pressure on Patients with Acute Coronary Syndrome and Nonsleepy Obstructive Sleep Apnoea, and Sleep Apnoea Cardiovascular Endpoints Study r"],"journal":["European heart journal"],"pagination":["ehaf447"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12874658"],"repository":["biostudies-literature"],"pubmed_title":["Cardiovascular benefit of continuous positive airway pressure according to high-risk obstructive sleep apnoea: a multi-trial analysis."],"pmcid":["PMC12874658"],"funding_grant_id":["R01 HL153874","19CDA34660137","R01HL168067","R01 HL168067","K23 HL159259","SR-2217","521-2011-537","R01HL153874","R01 HL146697","R21 HL161766","521-2013-3439","R01HL146697","K23HL159259","20090708","20080592","20100664"],"pubmed_authors":["McEvoy D","Peker Y","Vena D","Pinilla L","Messineo L","Anderson CS","Esmaeili N","Baumert M","Barbe F","Zinchuk A","White DP","Redline S","Azarbarzin A","Sanchez-de-la-Torre M","Sands SA","Alex R","Loffler KA","Gottlieb DJ","Wellman A"],"additional_accession":[]},"is_claimable":false,"name":"Cardiovascular benefit of continuous positive airway pressure according to high-risk obstructive sleep apnoea: a multi-trial analysis.","description":"<h4>Background and aims</h4>Randomized trials of continuous positive airway pressure (CPAP) treatment for obstructive sleep apnoea (OSA) in patients with cardiovascular disease have not detected reduced risk of major adverse cardiovascular and cerebrovascular events (MACCEs). This study tested whether the cardiovascular benefit of CPAP occurs preferentially in high-risk OSA, characterized by greater OSA-related heart rate acceleration or hypoxaemia.<h4>Methods</h4>In a post hoc analysis of pooled Randomized Intervention with Continuous Positive Airway Pressure in Coronary Artery Disease and Obstructive Sleep Apnoea, Impact of Continuous Positive Airway Pressure on Patients with Acute Coronary Syndrome and Nonsleepy Obstructive Sleep Apnoea, and Sleep Apnoea Cardiovascular Endpoints Study r","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Aug","modification":"2026-07-15T11:50:35.748Z","creation":"2026-07-06T03:08:46.404Z"},"accession":"S-EPMC12874658","cross_references":{"pubmed":["40794640"],"doi":["10.1093/eurheartj/ehaf447"]}}