{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Liu K"],"funding":["College Students' Innovative Entrepreneurial Training Plan Program","College Students’ Innovative Entrepreneurial Training Plan Program","the National Natural Science Foundation of China"],"pagination":["50"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12876095"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["49(1)"],"pubmed_abstract":["Ferroptosis, an iron-dependent form of cell death driven by lipid peroxidation, plays a critical role in the progression of asthma, yet its therapeutic modulation remains underexplored. Luteolin (Lut), a natural flavonoid known for its anti-inflammatory properties, presents a potential candidate for targeting ferroptosis in asthma. However, the precise mechanisms underlying its therapeutic effects are unclear. This study used a combination of bioinformatics, network pharmacology, molecular docking, and in vitro and in vivo experiments to investigate the role of luteolin in the treatment of ferroptosis in asthma. A collection of natural flavonoid compounds with high oral bioavailability and drug-like properties was assembled from the Chinese herbal medicine database. Through network pharmac"],"journal":["Inflammation"],"pubmed_title":["Luteolin Attenuates Asthma Via Inhibiting ALOX15 Mediated Bronchial Epithelial Cell Ferroptosis."],"pmcid":["PMC12876095"],"funding_grant_id":["(202410571002, S202510571072, S202510571064)","(82370564)"],"pubmed_authors":["Liu K","Huang T","Lai T","Qiu S","Luo L","Wang W","Deng M","Zhao Y"],"additional_accession":[]},"is_claimable":false,"name":"Luteolin Attenuates Asthma Via Inhibiting ALOX15 Mediated Bronchial Epithelial Cell Ferroptosis.","description":"Ferroptosis, an iron-dependent form of cell death driven by lipid peroxidation, plays a critical role in the progression of asthma, yet its therapeutic modulation remains underexplored. Luteolin (Lut), a natural flavonoid known for its anti-inflammatory properties, presents a potential candidate for targeting ferroptosis in asthma. However, the precise mechanisms underlying its therapeutic effects are unclear. This study used a combination of bioinformatics, network pharmacology, molecular docking, and in vitro and in vivo experiments to investigate the role of luteolin in the treatment of ferroptosis in asthma. A collection of natural flavonoid compounds with high oral bioavailability and drug-like properties was assembled from the Chinese herbal medicine database. Through network pharmac","dates":{"release":"2026-01-01T00:00:00Z","publication":"2026 Jan","modification":"2026-07-15T09:16:05.892Z","creation":"2026-07-02T03:08:59.864Z"},"accession":"S-EPMC12876095","cross_references":{"pubmed":["41547709"],"doi":["10.1007/s10753-025-02421-2"]}}