biostudies-literatureLiu KCollege Students' Innovative Entrepreneurial Training Plan ProgramCollege Students’ Innovative Entrepreneurial Training Plan Programthe National Natural Science Foundation of China50https://www.ebi.ac.uk/biostudies/studies/S-EPMC12876095biostudies-literatureUnknown49(1)Ferroptosis, an iron-dependent form of cell death driven by lipid peroxidation, plays a critical role in the progression of asthma, yet its therapeutic modulation remains underexplored. Luteolin (Lut), a natural flavonoid known for its anti-inflammatory properties, presents a potential candidate for targeting ferroptosis in asthma. However, the precise mechanisms underlying its therapeutic effects are unclear. This study used a combination of bioinformatics, network pharmacology, molecular docking, and in vitro and in vivo experiments to investigate the role of luteolin in the treatment of ferroptosis in asthma. A collection of natural flavonoid compounds with high oral bioavailability and drug-like properties was assembled from the Chinese herbal medicine database. Through network pharmacInflammationLuteolin Attenuates Asthma Via Inhibiting ALOX15 Mediated Bronchial Epithelial Cell Ferroptosis.PMC12876095(202410571002, S202510571072, S202510571064)(82370564)Liu KHuang TLai TQiu SLuo LWang WDeng MZhao YfalseLuteolin Attenuates Asthma Via Inhibiting ALOX15 Mediated Bronchial Epithelial Cell Ferroptosis.Ferroptosis, an iron-dependent form of cell death driven by lipid peroxidation, plays a critical role in the progression of asthma, yet its therapeutic modulation remains underexplored. Luteolin (Lut), a natural flavonoid known for its anti-inflammatory properties, presents a potential candidate for targeting ferroptosis in asthma. However, the precise mechanisms underlying its therapeutic effects are unclear. This study used a combination of bioinformatics, network pharmacology, molecular docking, and in vitro and in vivo experiments to investigate the role of luteolin in the treatment of ferroptosis in asthma. A collection of natural flavonoid compounds with high oral bioavailability and drug-like properties was assembled from the Chinese herbal medicine database. Through network pharmac2026-01-01T00:00:00Z2026 Jan2026-07-15T09:16:05.892Z2026-07-02T03:08:59.864ZS-EPMC128760954154770910.1007/s10753-025-02421-2