{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Lei X"],"funding":["National Institute of Allergy and Infectious Diseases","NIAID NIH HHS","STARR Cancer Consortium","Research Foundation for the State University of New York","Mark Foundation For Cancer Research","DOD Peer Reviewed Cancer Research Program","G. Harold and Leila Y. Mathers Foundation","National Institute of General Medical Sciences","NIGMS NIH HHS"],"pagination":["e011570"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12878199"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["14(2)"],"pubmed_abstract":["<h4>Background</h4>Colorectal cancer (CRC) is a leading cause of cancer-related death and remains a significant global health challenge. Cancer vaccines have emerged as a promising immunotherapy for long-term tumor control. While <i>Listeria monocytogenes</i> (<i>Lm</i>)-based intravenous vaccines can generate tumor-reactive CD8 T cells, clinical trial success has been limited. Here, we sought to determine whether <i>in vivo</i> targeting of gastrointestinal tissues with foodborne delivery of <i>Lm</i>-based cancer vaccines controlled tumor growth in murine models of CRC.<h4>Methods</h4>The ActA and InlB virulence genes were deleted from a mouse-adapted <i>Lm</i> strain expressing ovalbumin and containing an internalin A mutation (InlA<sup>M</sup> <i>Lm</i>-ova) that allows epithelial cell"],"journal":["Journal for immunotherapy of cancer"],"pubmed_title":["Oral immunization with &lt;i&gt;Listeria monocytogenes&lt;/i&gt; vaccine enhances immunotherapy for protective immunity in murine models of colorectal cancer."],"pmcid":["PMC12878199"],"funding_grant_id":["I13-0052","N/A","T32 GM148331","20-028-EDV","W81XWH-18-1-0217","R01 AI172919","R01AI172919"],"pubmed_authors":["Chu TH","Beyaz S","Ozler KA","Westcott PMK","Chung C","Qiu Z","Li X","Lei X","Zhang Y","Sheridan BS","Yang R","Yu Y","Burgac M"],"additional_accession":[]},"is_claimable":false,"name":"Oral immunization with &lt;i&gt;Listeria monocytogenes&lt;/i&gt; vaccine enhances immunotherapy for protective immunity in murine models of colorectal cancer.","description":"<h4>Background</h4>Colorectal cancer (CRC) is a leading cause of cancer-related death and remains a significant global health challenge. Cancer vaccines have emerged as a promising immunotherapy for long-term tumor control. While <i>Listeria monocytogenes</i> (<i>Lm</i>)-based intravenous vaccines can generate tumor-reactive CD8 T cells, clinical trial success has been limited. Here, we sought to determine whether <i>in vivo</i> targeting of gastrointestinal tissues with foodborne delivery of <i>Lm</i>-based cancer vaccines controlled tumor growth in murine models of CRC.<h4>Methods</h4>The ActA and InlB virulence genes were deleted from a mouse-adapted <i>Lm</i> strain expressing ovalbumin and containing an internalin A mutation (InlA<sup>M</sup> <i>Lm</i>-ova) that allows epithelial cell","dates":{"release":"2026-01-01T00:00:00Z","publication":"2026 Feb","modification":"2026-07-16T03:13:13.88Z","creation":"2026-07-09T10:30:58.729Z"},"accession":"S-EPMC12878199","cross_references":{"pubmed":["41644269"],"doi":["10.1136/jitc-2025-011570"]}}