biostudies-literatureUnknown8(1)Abboud AInstitut Universitaire sur les DépendancesMinistère de la Santé et des Services sociaux<h4>Background</h4>Cannabidiol (CBD), a phytocannabinoid produced by Cannabis sativa, is widely consumed and interacts with components of the endocannabinoid system, including enzymes and receptors, through indirect and complex mechanisms. However, how CBD influences endogenous cannabinoids such as anandamide (AEA), and related N-acylethanolamines like N-palmitoylethanolamine (PEA) and N-oleoylethanolamine (OEA), remains poorly understood. This study investigates the acute impact of marketed CBD doses on the plasmatic levels of these signaling lipids in occasional cannabis users, addressing a critical gap in understanding the biological effects of low-dose CBD in non-therapeutic contexts.<h4>Methods</h4>In a triple-blind, placebo-controlled, randomized crossover trial, 70 healthy volunteerJournal of cannabis research20https://www.ebi.ac.uk/biostudies/studies/S-EPMC12879445biostudies-literatureSex-specific association between low oral doses of cannabidiol (CBD) and plasma concentration of anandamide (AEA), N-palmitoylethanolamine (PEA) and N-oleoylethanolamine (OEA) in healthy occasional cannabis users.PMC12879445Abboud AJutras-Aswad DChester LAHebert FOfalseSex-specific association between low oral doses of cannabidiol (CBD) and plasma concentration of anandamide (AEA), N-palmitoylethanolamine (PEA) and N-oleoylethanolamine (OEA) in healthy occasional cannabis users.<h4>Background</h4>Cannabidiol (CBD), a phytocannabinoid produced by Cannabis sativa, is widely consumed and interacts with components of the endocannabinoid system, including enzymes and receptors, through indirect and complex mechanisms. However, how CBD influences endogenous cannabinoids such as anandamide (AEA), and related N-acylethanolamines like N-palmitoylethanolamine (PEA) and N-oleoylethanolamine (OEA), remains poorly understood. This study investigates the acute impact of marketed CBD doses on the plasmatic levels of these signaling lipids in occasional cannabis users, addressing a critical gap in understanding the biological effects of low-dose CBD in non-therapeutic contexts.<h4>Methods</h4>In a triple-blind, placebo-controlled, randomized crossover trial, 70 healthy volunteer2026-01-01T00:00:00Z2026 Jan2026-07-15T06:54:46.831Z2026-06-30T03:30:29.269ZS-EPMC128794454151438510.1186/s42238-025-00356-x