{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["21(2)"],"submitter":["Zhang X"],"pubmed_abstract":["<h4>Background</h4>Myocardial ischemia-reperfusion injury (I/R) significantly exacerbates cardiomyocyte damage post-recanalization therapy in acute myocardial infarction. Pyroptosis and the NLRP3 inflammasome are crucial in I/R, yet the precise mechanism remains unclear.<h4>Materials and methods</h4>Transcriptomics, proteomics, and single-cell transcriptomics were employed to examine cellular subtype changes and pyroptosis-associated gene regulation in I/R. Differential pyroptosis-related genes were identified from transcriptomics data and validated with proteomics. Single-cell RNA sequencing assessed pyroptosis levels and intercellular communication. Mouse myocardial I/R and human cardiomyocyte hypoxia/reoxygenation (H/R) models were used to explore STING overexpression/silencing effects "],"journal":["PloS one"],"pagination":["e0341839"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12880705"],"repository":["biostudies-literature"],"pubmed_title":["Multi-omics analysis reveals STING activation mediates NLRP3-related pyroptosis and exacerbates myocardial ischemia-reperfusion injury."],"pmcid":["PMC12880705"],"pubmed_authors":["Zhou L","Jia S","Zhang X","Wu P","Cong G","Ma X","Ma Y","Yan R","Zhu B","Gu A"],"additional_accession":[]},"is_claimable":false,"name":"Multi-omics analysis reveals STING activation mediates NLRP3-related pyroptosis and exacerbates myocardial ischemia-reperfusion injury.","description":"<h4>Background</h4>Myocardial ischemia-reperfusion injury (I/R) significantly exacerbates cardiomyocyte damage post-recanalization therapy in acute myocardial infarction. Pyroptosis and the NLRP3 inflammasome are crucial in I/R, yet the precise mechanism remains unclear.<h4>Materials and methods</h4>Transcriptomics, proteomics, and single-cell transcriptomics were employed to examine cellular subtype changes and pyroptosis-associated gene regulation in I/R. Differential pyroptosis-related genes were identified from transcriptomics data and validated with proteomics. Single-cell RNA sequencing assessed pyroptosis levels and intercellular communication. Mouse myocardial I/R and human cardiomyocyte hypoxia/reoxygenation (H/R) models were used to explore STING overexpression/silencing effects ","dates":{"release":"2026-01-01T00:00:00Z","publication":"2026","modification":"2026-07-05T03:16:48.299Z","creation":"2026-07-05T03:12:22.965Z"},"accession":"S-EPMC12880705","cross_references":{"pubmed":["41650015"],"doi":["10.1371/journal.pone.0341839"]}}