{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Lin Z"],"funding":["NIGMS NIH HHS"],"pagination":["1664275"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12893633"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["12"],"pubmed_abstract":["Halogenated molecules produced by marine algae are thought to be defensive secondary metabolites. The extraordinarily high concentration of bromoform in the seaweed <i>Asparagopsis</i>-up to 8% dry tissue weight-challenges the exclusivity of this paradigm. In this report, we provide evidence that the <i>mbb1</i> gene which encodes the bromoform producing halogenase is among the most highly transcribed genes in <i>Asparagopsis</i> tissue, with the resulting Mbb1 protein abundance rivaling that of enzymes involved in photosynthesis and carbon fixation. When the seaweed was stressed with light, transcripts for both <i>mbb1</i> and for proteins involved in photosynthesis were significantly downregulated. Conversely, heat stress modestly upregulated some photosynthesis genes but had no impact o"],"journal":["Frontiers in Marine Science"],"pubmed_title":["Detection of unusually high transcriptomic and proteomic abundance of bromoform-synthesizing halogenase in marine macroalgae &lt;i&gt;Asparagopsis taxiformis&lt;/i&gt;."],"pmcid":["PMC12893633"],"funding_grant_id":["R35 GM142882"],"pubmed_authors":["Smith JE","Zhou L","Islam S","Schmidt EW","Hargrave MS","Agarwal V","Lin Z","Singh R","Xie R"],"additional_accession":[]},"is_claimable":false,"name":"Detection of unusually high transcriptomic and proteomic abundance of bromoform-synthesizing halogenase in marine macroalgae &lt;i&gt;Asparagopsis taxiformis&lt;/i&gt;.","description":"Halogenated molecules produced by marine algae are thought to be defensive secondary metabolites. The extraordinarily high concentration of bromoform in the seaweed <i>Asparagopsis</i>-up to 8% dry tissue weight-challenges the exclusivity of this paradigm. In this report, we provide evidence that the <i>mbb1</i> gene which encodes the bromoform producing halogenase is among the most highly transcribed genes in <i>Asparagopsis</i> tissue, with the resulting Mbb1 protein abundance rivaling that of enzymes involved in photosynthesis and carbon fixation. When the seaweed was stressed with light, transcripts for both <i>mbb1</i> and for proteins involved in photosynthesis were significantly downregulated. Conversely, heat stress modestly upregulated some photosynthesis genes but had no impact o","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025","modification":"2026-07-15T15:36:06.235Z","creation":"2026-07-06T03:10:59.559Z"},"accession":"S-EPMC12893633","cross_references":{"pubmed":["41684644"],"doi":["10.3389/fmars.2025.1664275"]}}