{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["16(9)"],"submitter":["Mandigo JA"],"pubmed_abstract":["Quantitative appreciation of electronic substituent effects is beneficial across the chemical sciences, from reaction kinetics and catalysis to functional materials design and enzymatic processes. While Hammett parameters (<i>σ</i> constants) constitute the most widely invoked paradigm, their determination for structurally complex functional groups is often impractical by traditional empirical means. Herein, we demonstrate that the reversible one-step, 2-e<sup>-</sup> reduction of linearly functionalized 1,1',3,3'-tetraethoxycarbonyl-6,6'-biazulene provides a simple electrochemical readout of effective Hammett constants. By design, the values obtained align closely with the conventional <i>σ</i> <sub>p</sub> descriptors pertaining to benzenoid systems. This approach not only helps reevalua"],"journal":["RSC advances"],"pagination":["8371-8379"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12893891"],"repository":["biostudies-literature"],"pubmed_title":["6,6'-Biazulenic core as a platform for unlocking Hammett constants &lt;i&gt;via&lt;/i&gt; electrochemical free-energy relationships."],"pmcid":["PMC12893891"],"pubmed_authors":["Mandigo JA","Kelsey SR","Barybin MV","Sabala RC","Dairo MK","Weghorn CR","Berrie CL","Applegate JC","Fair R","Janzen DE","Thompson WH"],"additional_accession":[]},"is_claimable":false,"name":"6,6'-Biazulenic core as a platform for unlocking Hammett constants &lt;i&gt;via&lt;/i&gt; electrochemical free-energy relationships.","description":"Quantitative appreciation of electronic substituent effects is beneficial across the chemical sciences, from reaction kinetics and catalysis to functional materials design and enzymatic processes. While Hammett parameters (<i>σ</i> constants) constitute the most widely invoked paradigm, their determination for structurally complex functional groups is often impractical by traditional empirical means. Herein, we demonstrate that the reversible one-step, 2-e<sup>-</sup> reduction of linearly functionalized 1,1',3,3'-tetraethoxycarbonyl-6,6'-biazulene provides a simple electrochemical readout of effective Hammett constants. By design, the values obtained align closely with the conventional <i>σ</i> <sub>p</sub> descriptors pertaining to benzenoid systems. This approach not only helps reevalua","dates":{"release":"2026-01-01T00:00:00Z","publication":"2026 Feb","modification":"2026-07-15T17:28:52.867Z","creation":"2026-07-07T03:08:46.659Z"},"accession":"S-EPMC12893891","cross_references":{"pubmed":["41694097"],"doi":["10.1039/d6ra00120c"]}}