biostudies-literatureUnknown399(1)Evans KMedizinische Hochschule Hannover (MHH)As Na⁺-K⁺-ATPase (NKA) inhibitors ('cardiac glycosides') have declining rates of prescriptions because of their narrow therapeutic window, high toxicity and questionable clinical efficacy in cardiological indications, the question arises what the future of these drugs entails. In this paper, we researched and analysed newer uses of these drugs outside of their traditional indications, also referred to as repurposing. On ClinicalTrials.gov, we analysed the trials on NKA inhibitors including the scientific value of published trials. Of 306 trials to be analysed, only 40 were for repurposed use, of which 17 had a publication. Malignant diseases and foetal demise for late abortion are the most prominent indications. However, the quality of the clinical studies analysed waNaunyn-Schmiedeberg's archives of pharmacology721-744https://www.ebi.ac.uk/biostudies/studies/S-EPMC12894119biostudies-literatureRepurposing of NKA inhibitors ('cardiac glycosides'): a critical analysis.PMC12894119Seifert REvans KfalseRepurposing of NKA inhibitors ('cardiac glycosides'): a critical analysis.As Na⁺-K⁺-ATPase (NKA) inhibitors ('cardiac glycosides') have declining rates of prescriptions because of their narrow therapeutic window, high toxicity and questionable clinical efficacy in cardiological indications, the question arises what the future of these drugs entails. In this paper, we researched and analysed newer uses of these drugs outside of their traditional indications, also referred to as repurposing. On ClinicalTrials.gov, we analysed the trials on NKA inhibitors including the scientific value of published trials. Of 306 trials to be analysed, only 40 were for repurposed use, of which 17 had a publication. Malignant diseases and foetal demise for late abortion are the most prominent indications. However, the quality of the clinical studies analysed wa2026-01-01T00:00:00Z2026 Jan2026-07-16T09:40:18.415Z2026-07-09T10:47:09.042ZS-EPMC128941194067958810.1007/s00210-025-04443-x