{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["17"],"submitter":["Guo Y"],"pubmed_abstract":["While probiotics like <i>Enterococcus faecium</i> are known for gut health benefits, their potential anti-aging effects are poorly understood. This study investigated whether <i>E. faecium</i> fermentation broth delays aging and explored its mechanisms. Using a mouse model, lifespan assays suggested that the <i>E. faecium fermentation</i> broth may contribute to lifespan extension, indicating anti-aging properties. Microbiome analysis showed it modulated gut microbiota, increasing beneficial <i>Akkermansia</i> abundance. Key active components identified included myo-inositol (promoting hair follicle growth), D-ribose, and secreted proteins. While myo-inositol increased the abundance of <i>Lactobacillus reuteri</i> and <i>Lactobacillus johnsonii</i>, it did not increase <i>Akkermansia</i>. "],"journal":["Frontiers in microbiology"],"pagination":["1680593"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12894319"],"repository":["biostudies-literature"],"pubmed_title":["&lt;i&gt;Enterococcus faecium&lt;/i&gt; secreted the NlpC/P60 family protein to enhance host immunity and indirectly increases &lt;i&gt;Akkermansia muciniphila&lt;/i&gt; for slowing aging."],"pmcid":["PMC12894319"],"pubmed_authors":["Yang X","Zhang F","Guo Y","Fu W","Xu C","Zou S","Li R"],"additional_accession":[]},"is_claimable":false,"name":"&lt;i&gt;Enterococcus faecium&lt;/i&gt; secreted the NlpC/P60 family protein to enhance host immunity and indirectly increases &lt;i&gt;Akkermansia muciniphila&lt;/i&gt; for slowing aging.","description":"While probiotics like <i>Enterococcus faecium</i> are known for gut health benefits, their potential anti-aging effects are poorly understood. This study investigated whether <i>E. faecium</i> fermentation broth delays aging and explored its mechanisms. Using a mouse model, lifespan assays suggested that the <i>E. faecium fermentation</i> broth may contribute to lifespan extension, indicating anti-aging properties. Microbiome analysis showed it modulated gut microbiota, increasing beneficial <i>Akkermansia</i> abundance. Key active components identified included myo-inositol (promoting hair follicle growth), D-ribose, and secreted proteins. While myo-inositol increased the abundance of <i>Lactobacillus reuteri</i> and <i>Lactobacillus johnsonii</i>, it did not increase <i>Akkermansia</i>. ","dates":{"release":"2026-01-01T00:00:00Z","publication":"2026","modification":"2026-07-15T16:39:37.517Z","creation":"2026-07-07T03:08:34.31Z"},"accession":"S-EPMC12894319","cross_references":{"pubmed":["41695942"],"doi":["10.3389/fmicb.2026.1680593"]}}