biostudies-literatureZhao HScience and Technology Planning Project of Chengguan District, Lanzhou CityHongliu Outstanding Youth program 2023Key Research and Development Program of Gannan PrefectureNational Natural Science Foundation of China409https://www.ebi.ac.uk/biostudies/studies/S-EPMC12896772biostudies-literatureUnknown15(3)Fructose dietary intake is one of the most common risk factors for hyperuricemia, which is a critical threat to human health, and the lack of an effective biological intervention method is the main problem in preventing hyperuricemia caused by fructose intake. <i>Lacticaseibacillus rhamnosus</i> Fmb14 (<i>L. rhamnosus</i> Fmb14) has a fructose-metabolizing ability to produce extracellular polysaccharides (EPSs), and the yield of EPSs reached 0.50 and 0.42 g/L after 48 h of fermentation in liquid media of glucose-MRS and fructose-MRS. Six pure polysaccharide components were obtained after purification. A hyperuricemic mouse model was subsequently established by feeding a 60% high-fructose diet with potassium oxyazinate for 8 weeks, and the results revealed that <i>L. rhamnosus</i> Fmb14 andFoods (Basel, Switzerland)Exopolysaccharides from &lt;i&gt;Lacticaseibacillus rhamnosus&lt;/i&gt; Fmb14 Ameliorate Fructose-Induced Hyperuricemia and Fatty Liver via Gut Modulation.PMC12896772grants 2024RCCX0022 to Song Ligrants 2025ZY1N007 to Song Ligrants 062402 to Zhao Hongyuangrants 32072182 to Zhaoxin LuSong LZhang ZLu YLu ZTang CChen XZhao HfalseExopolysaccharides from &lt;i&gt;Lacticaseibacillus rhamnosus&lt;/i&gt; Fmb14 Ameliorate Fructose-Induced Hyperuricemia and Fatty Liver via Gut Modulation.Fructose dietary intake is one of the most common risk factors for hyperuricemia, which is a critical threat to human health, and the lack of an effective biological intervention method is the main problem in preventing hyperuricemia caused by fructose intake. <i>Lacticaseibacillus rhamnosus</i> Fmb14 (<i>L. rhamnosus</i> Fmb14) has a fructose-metabolizing ability to produce extracellular polysaccharides (EPSs), and the yield of EPSs reached 0.50 and 0.42 g/L after 48 h of fermentation in liquid media of glucose-MRS and fructose-MRS. Six pure polysaccharide components were obtained after purification. A hyperuricemic mouse model was subsequently established by feeding a 60% high-fructose diet with potassium oxyazinate for 8 weeks, and the results revealed that <i>L. rhamnosus</i> Fmb14 and2026-01-01T00:00:00Z2026 Jan2026-07-07T03:14:35.953Z2026-07-07T03:09:50.636ZS-EPMC128967724168299710.3390/foods15030409