{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Ma F"],"funding":["Science and Technology Department of Inner Mongolia Autonomous Region"],"pagination":["561"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12897461"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["15(3)"],"pubmed_abstract":["Elucidating the molecular mechanisms underlying beef quality differences is crucial for precision breeding of high-quality cattle. In this study, we first characterized the myofibrillar morphology of high-quality (H group) and low-quality (L group) beef samples using hematoxylin-eosin (HE) staining. Transcriptomic and metabolomic analyses were then conducted to reveal the molecular regulatory basis of quality variation. HE staining revealed highly significant differences in muscle fiber area and diameter between H and L groups (<i>p</i> < 0.01), along with significant differences in muscle fiber density (<i>p</i> < 0.05), but no significant differences in muscle fiber perimeter. Furthermore, by focusing on five core metabolic pathways shared across the transcriptome and metabolome datasets"],"journal":["Foods (Basel, Switzerland)"],"pubmed_title":["Integrating Transcriptomics and Metabolomics to Elucidate the Molecular Mechanisms Underlying Beef Quality Variations."],"pmcid":["PMC12897461"],"funding_grant_id":["2022JBGS0025","2023YFHH0058"],"pubmed_authors":["Zhang W","Zhou L","Na R","Guo L","Li S","Shi C","Bao Y","Zhu L","Gu M","Ma F","Sun J"],"additional_accession":[]},"is_claimable":false,"name":"Integrating Transcriptomics and Metabolomics to Elucidate the Molecular Mechanisms Underlying Beef Quality Variations.","description":"Elucidating the molecular mechanisms underlying beef quality differences is crucial for precision breeding of high-quality cattle. In this study, we first characterized the myofibrillar morphology of high-quality (H group) and low-quality (L group) beef samples using hematoxylin-eosin (HE) staining. Transcriptomic and metabolomic analyses were then conducted to reveal the molecular regulatory basis of quality variation. HE staining revealed highly significant differences in muscle fiber area and diameter between H and L groups (<i>p</i> < 0.01), along with significant differences in muscle fiber density (<i>p</i> < 0.05), but no significant differences in muscle fiber perimeter. Furthermore, by focusing on five core metabolic pathways shared across the transcriptome and metabolome datasets","dates":{"release":"2026-01-01T00:00:00Z","publication":"2026 Feb","modification":"2026-07-07T03:11:04.933Z","creation":"2026-07-07T03:08:34.5Z"},"accession":"S-EPMC12897461","cross_references":{"pubmed":["41683148"],"doi":["10.3390/foods15030561"]}}