biostudies-literatureUnknown15(3)Hoglund ZT<b>Background:</b> Traumatic brain injury (TBI) imposes a substantial public health burden through long-term physical, cognitive, and psychiatric effects. This includes substance use disorders (SUDs) for which TBI is a demonstrated risk factor; however, prior studies have not comprehensively compared relative incidences of SUD subtypes post-TBI or differences between intracranial hemorrhage (ICH) and non-ICH TBI in patients without prior SUD history. This global retrospective analysis using the TriNetX database aims to quantify new-onset SUD incidence post-TBI in the largest cohort of patients evaluated to date, with cohorts stratified by SUD subtype and ICH versus non-ICH TBI, to highlight opportunities for post-injury care models to mitigate SUD risk. <b>Methods:</b> De-identified data fJournal of clinical medicine1182https://www.ebi.ac.uk/biostudies/studies/S-EPMC12897771biostudies-literatureRelative Incidence of New-Onset Substance Use Disorders Following Traumatic Brain Injury: A Global Retrospective Multicenter Analysis Using the TriNetX Database.PMC12897771Scott KWBurkhardt JKArena JDSrinivasan VMClaus CFHeitkotter HHoglund ZTGriepp DWTurnbull JHelfand AISollenberger CRosado-Philippi JfalseRelative Incidence of New-Onset Substance Use Disorders Following Traumatic Brain Injury: A Global Retrospective Multicenter Analysis Using the TriNetX Database.<b>Background:</b> Traumatic brain injury (TBI) imposes a substantial public health burden through long-term physical, cognitive, and psychiatric effects. This includes substance use disorders (SUDs) for which TBI is a demonstrated risk factor; however, prior studies have not comprehensively compared relative incidences of SUD subtypes post-TBI or differences between intracranial hemorrhage (ICH) and non-ICH TBI in patients without prior SUD history. This global retrospective analysis using the TriNetX database aims to quantify new-onset SUD incidence post-TBI in the largest cohort of patients evaluated to date, with cohorts stratified by SUD subtype and ICH versus non-ICH TBI, to highlight opportunities for post-injury care models to mitigate SUD risk. <b>Methods:</b> De-identified data f2026-01-01T00:00:00Z2026 Feb2026-07-07T03:11:45.782Z2026-07-07T03:08:37.544ZS-EPMC128977714168286210.3390/jcm15031182