{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["27(3)"],"submitter":["Kiatlertpongsa T"],"funding":["the Thailand Science Research and Innovation Fundamental Fund, fiscal year 2025","Thammasat Postdoctoral Fellowship"],"pubmed_abstract":["The reliance on synthetic repellents such as N,N-diethyl-meta-toluamide (DEET) has raised health and environmental concerns, prompting the search for safer, plant-based alternatives. Catnip (<i>Nepeta cataria</i> L.), a rich source of iridoid monoterpenes, particularly nepetalactones, known for strong insect-repellent activity. However, their efficient extraction and molecular mechanisms in insect inhibition remains challenging. This study examined the chemical composition, protein-ligand interactions, and safety profiles of nepetalactones in comparison with DEET, with particular focus on mosquito odorant-binding proteins (OBPs) from <i>Anopheles gambiae</i> (<i>Agam</i>OBP), <i>Culex quinquefasciatus</i> (<i>Cqui</i>OBP), and <i>Aedes aegypti</i> (<i>Aaeg</i>OBP). GC-MS/MS analysis identi"],"journal":["International journal of molecular sciences"],"pagination":["1572"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12897829"],"repository":["biostudies-literature"],"pubmed_title":["A Safer Alternative Bio-Repellent: Targeting Mosquito Odorant-Binding Proteins with Catnip-Derived Nepetalactones from &lt;i&gt;Nepeta cataria&lt;/i&gt; Leaves."],"pmcid":["PMC12897829"],"pubmed_authors":["Saetan J","Kiatlertpongsa T","Nonkhwao S","Duangprom S","Janpan P","Charoenrit J","Sobhon P","Amonruttanapun P","Songkoomkrong S","Daduang S","Kornthong N"],"additional_accession":[]},"is_claimable":false,"name":"A Safer Alternative Bio-Repellent: Targeting Mosquito Odorant-Binding Proteins with Catnip-Derived Nepetalactones from &lt;i&gt;Nepeta cataria&lt;/i&gt; Leaves.","description":"The reliance on synthetic repellents such as N,N-diethyl-meta-toluamide (DEET) has raised health and environmental concerns, prompting the search for safer, plant-based alternatives. Catnip (<i>Nepeta cataria</i> L.), a rich source of iridoid monoterpenes, particularly nepetalactones, known for strong insect-repellent activity. However, their efficient extraction and molecular mechanisms in insect inhibition remains challenging. This study examined the chemical composition, protein-ligand interactions, and safety profiles of nepetalactones in comparison with DEET, with particular focus on mosquito odorant-binding proteins (OBPs) from <i>Anopheles gambiae</i> (<i>Agam</i>OBP), <i>Culex quinquefasciatus</i> (<i>Cqui</i>OBP), and <i>Aedes aegypti</i> (<i>Aaeg</i>OBP). GC-MS/MS analysis identi","dates":{"release":"2026-01-01T00:00:00Z","publication":"2026 Feb","modification":"2026-07-07T03:16:24.589Z","creation":"2026-07-07T03:08:47.808Z"},"accession":"S-EPMC12897829","cross_references":{"pubmed":["41683995"],"doi":["10.3390/ijms27031572"]}}