{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Guinart-Cuadra A"],"funding":["Instituto de Salud Carlos III"],"pagination":["1258"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12897947"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["27(3)"],"pubmed_abstract":["Alcohol-associated hepatitis (AH) is the most severe clinical manifestation of alcohol-associated liver disease. Corticosteroids are the only disease-specific therapy shown to improve short-term survival. Currently, no non-invasive markers are available to predict patient response to corticosteroids or long-term survival in AH. This study investigates whether surface antigens on plasma extracellular vesicles (EVs), key mediators of intercellular communication, can reflect the underlying immune dysregulation in AH and serve as prognostic markers. Patients with AH were prospectively enrolled between 2020 and 2024. Blood samples were collected before corticosteroid initiation during the first 24 h of hospitalization. EVs were characterized using nanoparticle tracking analysis, cryo-electron m"],"journal":["International journal of molecular sciences"],"pubmed_title":["Immune and Endothelial-Related Extracellular Vesicles Are Associated with Corticosteroid Response and Mortality in Alcohol-Associated Hepatitis."],"pmcid":["PMC12897947"],"funding_grant_id":["PI21/01995"],"pubmed_authors":["Camps M","Poca M","Gely C","Villalba J","Osuna-Gomez R","Bataller R","Soriano G","Mulet M","Falcon-Perez JM","Escorsell A","Szafranska J","Fajardo J","Argemi J","Brujats A","Dinamarca F","Sanchez-Ardid E","Guerrero R","Gonzalez E","Ferrero-Gregori A","Alvarado-Tapias E","Roman E","Guinart-Cuadra A","Canto E","Vidal S"],"additional_accession":[]},"is_claimable":false,"name":"Immune and Endothelial-Related Extracellular Vesicles Are Associated with Corticosteroid Response and Mortality in Alcohol-Associated Hepatitis.","description":"Alcohol-associated hepatitis (AH) is the most severe clinical manifestation of alcohol-associated liver disease. Corticosteroids are the only disease-specific therapy shown to improve short-term survival. Currently, no non-invasive markers are available to predict patient response to corticosteroids or long-term survival in AH. This study investigates whether surface antigens on plasma extracellular vesicles (EVs), key mediators of intercellular communication, can reflect the underlying immune dysregulation in AH and serve as prognostic markers. Patients with AH were prospectively enrolled between 2020 and 2024. Blood samples were collected before corticosteroid initiation during the first 24 h of hospitalization. EVs were characterized using nanoparticle tracking analysis, cryo-electron m","dates":{"release":"2026-01-01T00:00:00Z","publication":"2026 Jan","modification":"2026-07-07T03:10:41.252Z","creation":"2026-07-07T03:08:27.365Z"},"accession":"S-EPMC12897947","cross_references":{"pubmed":["41683683"],"doi":["10.3390/ijms27031258"]}}