{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["27(3)"],"submitter":["Wang L"],"pubmed_abstract":["Hemocompatibility is critical for intravenous hemoglobin-based oxygen carriers (HBOCs). We evaluated the hemocompatibility of polyethylene glycol-conjugated bovine hemoglobin (PEG-bHb) to facilitate its optimization and clinical translation. PEG-bHb was synthesized and characterized. In vitro hemocompatibility was assessed by incubating blood components with PEG-bHb (2.5-40 mg/mL), evaluating erythrocyte morphology/function, coagulation, complement activation, and leu kocyte phagocytosis. In vivo assessments in Wistar rats injecting PEG-bHb (50-100 mg/kg) included erythrocyte function, coagulation, complement activation, and histopathology. PEG-bHb exhibited increased hydrodynamic diameter, unaltered zeta potential, elevated colloidal osmotic pressure (COP) and viscosity, alongside a decre"],"journal":["International journal of molecular sciences"],"pagination":["1262"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12898566"],"repository":["biostudies-literature"],"pubmed_title":["Hemocompatibility Evaluation of PEGylated Bovine Hemoglobin."],"pmcid":["PMC12898566"],"pubmed_authors":["Li W","Zhao L","Zeng Q","Tao S","Chen Y","You G","Wang Y","Zhou H","Yu H","Wang L"],"additional_accession":[]},"is_claimable":false,"name":"Hemocompatibility Evaluation of PEGylated Bovine Hemoglobin.","description":"Hemocompatibility is critical for intravenous hemoglobin-based oxygen carriers (HBOCs). We evaluated the hemocompatibility of polyethylene glycol-conjugated bovine hemoglobin (PEG-bHb) to facilitate its optimization and clinical translation. PEG-bHb was synthesized and characterized. In vitro hemocompatibility was assessed by incubating blood components with PEG-bHb (2.5-40 mg/mL), evaluating erythrocyte morphology/function, coagulation, complement activation, and leu kocyte phagocytosis. In vivo assessments in Wistar rats injecting PEG-bHb (50-100 mg/kg) included erythrocyte function, coagulation, complement activation, and histopathology. PEG-bHb exhibited increased hydrodynamic diameter, unaltered zeta potential, elevated colloidal osmotic pressure (COP) and viscosity, alongside a decre","dates":{"release":"2026-01-01T00:00:00Z","publication":"2026 Jan","modification":"2026-07-07T03:10:36.129Z","creation":"2026-07-07T03:09:36.87Z"},"accession":"S-EPMC12898566","cross_references":{"pubmed":["41683691"],"doi":["10.3390/ijms27031262"]}}