{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["31(3)"],"submitter":["Chen W"],"pubmed_abstract":["Control of process-related impurities is of critical importance for developing an efficient and suitable synthetic process of an active pharmaceutical ingredient. In the study of a key intermediate of silodosin (KIS), two process-related impurities including the benzaldehyde impurity (BAI) and indole impurity (IDI) were prepared and fully characterized to determine their downstream fate. Under optimized conditions, BAI was formed in a yield of ~48% by treating KIS with 10% hydrogen peroxide at 60 °C. Interestingly, BAI would not be expected to be the major product under the apparent Baeyer-Villiger oxidative condition. Furthermore, by adding 20 mM FeCl<sub>3</sub> into the above 10% hydrogen peroxide solution, IDI became the major product in a yield of ~43% under this Fenton reaction-like "],"journal":["Molecules (Basel, Switzerland)"],"pagination":["462"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12898569"],"repository":["biostudies-literature"],"pubmed_title":["Preparation of Two Process-Related Impurities of a Key Intermediate of Silodosin Under Baeyer-Villiger and Fenton Conditions."],"pmcid":["PMC12898569"],"pubmed_authors":["Xi J","Zhou Q","Zhang J","Chen W","Bai Z","Jin J","Li M"],"additional_accession":[]},"is_claimable":false,"name":"Preparation of Two Process-Related Impurities of a Key Intermediate of Silodosin Under Baeyer-Villiger and Fenton Conditions.","description":"Control of process-related impurities is of critical importance for developing an efficient and suitable synthetic process of an active pharmaceutical ingredient. In the study of a key intermediate of silodosin (KIS), two process-related impurities including the benzaldehyde impurity (BAI) and indole impurity (IDI) were prepared and fully characterized to determine their downstream fate. Under optimized conditions, BAI was formed in a yield of ~48% by treating KIS with 10% hydrogen peroxide at 60 °C. Interestingly, BAI would not be expected to be the major product under the apparent Baeyer-Villiger oxidative condition. Furthermore, by adding 20 mM FeCl<sub>3</sub> into the above 10% hydrogen peroxide solution, IDI became the major product in a yield of ~43% under this Fenton reaction-like ","dates":{"release":"2026-01-01T00:00:00Z","publication":"2026 Jan","modification":"2026-07-09T13:12:01.426Z","creation":"2026-07-09T13:09:13.422Z"},"accession":"S-EPMC12898569","cross_references":{"pubmed":["41683439"],"doi":["10.3390/molecules31030462"]}}