{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Wang C"],"funding":["The Open Foundation of Key Laboratory of Taihu Basin Water Resources Management, Ministry of Water Resources","National Natural Science Foundation of China"],"pagination":["499"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12899096"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["15(3)"],"pubmed_abstract":["Thermophilic cyanobacteria are key models for thermotolerance and a promising source of thermophilic bioresources. Yet the subcellular basis of their stress resilience remains poorly resolved. Here, we focus on intracellular polyphosphate (polyP)-rich granules, termed \"stabilisomes,\" which have been implicated in stress adaptation. The lack of a high-purity, structure-preserving isolation method has been a major technical bottleneck hindering the elucidation of this resilience mechanism. This study describes a robust, structure-preserving purification strategy, boosting the granule-to-protein yield by over 10,000-fold compared with conventional methods. The specificity and structural integrity of this method are supported by the specific enrichment of complex proteomic (937 proteins) and m"],"journal":["Plants (Basel, Switzerland)"],"pubmed_title":["High-Purity Isolation of Polyphosphate-Rich Stabilisomes Defines Their Conserved Chemical Architecture in Thermophilic Cyanobacteria."],"pmcid":["PMC12899096"],"funding_grant_id":["Yk922001-C2","42307172","41871082"],"pubmed_authors":["Wang M","Yang L","Wang C","Zhou C","Song X","Yin J"],"additional_accession":[]},"is_claimable":false,"name":"High-Purity Isolation of Polyphosphate-Rich Stabilisomes Defines Their Conserved Chemical Architecture in Thermophilic Cyanobacteria.","description":"Thermophilic cyanobacteria are key models for thermotolerance and a promising source of thermophilic bioresources. Yet the subcellular basis of their stress resilience remains poorly resolved. Here, we focus on intracellular polyphosphate (polyP)-rich granules, termed \"stabilisomes,\" which have been implicated in stress adaptation. The lack of a high-purity, structure-preserving isolation method has been a major technical bottleneck hindering the elucidation of this resilience mechanism. This study describes a robust, structure-preserving purification strategy, boosting the granule-to-protein yield by over 10,000-fold compared with conventional methods. The specificity and structural integrity of this method are supported by the specific enrichment of complex proteomic (937 proteins) and m","dates":{"release":"2026-01-01T00:00:00Z","publication":"2026 Feb","modification":"2026-07-06T03:22:26.84Z","creation":"2026-07-06T03:11:12.815Z"},"accession":"S-EPMC12899096","cross_references":{"pubmed":["41681662"],"doi":["10.3390/plants15030499"]}}