biostudies-literatureVillani VEuropean Union - Next Generation EU495https://www.ebi.ac.uk/biostudies/studies/S-EPMC12899310biostudies-literatureUnknown18(3)<b>Background:</b><i>Malva sylvestris</i> (the common mallow) is an herbaceous species widely used in ethnobotanical practices to treat gastrointestinal, hepatic and urinary inflammation. <b>Objectives:</b> Despite these beneficial effects on human health, the antineoplastic potential of this plant has not yet been fully explored. Thus, in the present study, two human colon cancer cell lines (i.e., HCT-116 and Caco-2) were treated with an extract obtained from <i>M. sylvestris</i> flowers (MFE), whose composition in terms of phytochemicals and microRNAs has been recently published by our research group, to explore its potential bioactivity. <b>Methods/Results:</b> MTT and Trypan blue assays demonstrated that MFE reduced tumour cell growth without causing significant cytotoxicity or apoptosNutrients&lt;i&gt;Malva sylvestris&lt;/i&gt; Flower Extract Exhibits Antineoplastic Potential Against Human Colon Cancer Cell Lines and Induces &lt;i&gt;CDK2&lt;/i&gt; Transcript Instability via Plant miR160-5p.PMC12899310National Recovery and Resilience Plan (NRRP), Mission 4"Education and Research", Component 2"From Research to Business", Investment 1.4"Strengthening research structures for supporting the creation of National Centres, national R&D leaders on some Key EnaVillani VGismondi Afalse&lt;i&gt;Malva sylvestris&lt;/i&gt; Flower Extract Exhibits Antineoplastic Potential Against Human Colon Cancer Cell Lines and Induces &lt;i&gt;CDK2&lt;/i&gt; Transcript Instability via Plant miR160-5p.<b>Background:</b><i>Malva sylvestris</i> (the common mallow) is an herbaceous species widely used in ethnobotanical practices to treat gastrointestinal, hepatic and urinary inflammation. <b>Objectives:</b> Despite these beneficial effects on human health, the antineoplastic potential of this plant has not yet been fully explored. Thus, in the present study, two human colon cancer cell lines (i.e., HCT-116 and Caco-2) were treated with an extract obtained from <i>M. sylvestris</i> flowers (MFE), whose composition in terms of phytochemicals and microRNAs has been recently published by our research group, to explore its potential bioactivity. <b>Methods/Results:</b> MTT and Trypan blue assays demonstrated that MFE reduced tumour cell growth without causing significant cytotoxicity or apoptos2026-01-01T00:00:00Z2026 Feb2026-07-06T03:21:17.495Z2026-07-06T03:11:00.926ZS-EPMC128993104168331710.3390/nu18030495