biostudies-literatureCifuentes FFondo Nacional de Desarrollo Científico y Tecnológico352https://www.ebi.ac.uk/biostudies/studies/S-EPMC12899593biostudies-literatureUnknown15(3)Berries are an excellent source of bioactive compounds, particularly polyphenols, and have been widely used in folk medicine by the Mapuche people of southern Chile. In this study, a hydroalcoholic extract of <i>Berberis congestiflora</i> Gay (BE) was analyzed to determine its phytochemical composition and to evaluate its antioxidant capacity, vasorelaxant effects in rat aortas, and inhibitory activity on enzymes related to chronic non-communicable diseases, including exploration of a possible vasodilatory mechanism in isolated rat aortas. Antioxidant activity was assessed using Oxygen Radical Absorbance Capacity (ORAC), DPPH (2,2-diphenyl-1-picrylhydrazyl), and ABTS (2,2-azinobis-(3-ethylbenzothiazolin-6-sulfonic acid)) radical scavenging assays, as well as ferric reducing antioxidant powPlants (Basel, Switzerland)Polyphenolic Profile and Antioxidant and Aortic Endothelium Effect of &lt;i&gt;Michay&lt;/i&gt; (&lt;i&gt;Berberis congestiflora&lt;/i&gt; Gay) Collected in the Araucania Region of Chile.PMC128995931220075Palacios JParedes ALavado ARomero-Parra JSimirgiotis MJCifuentes FfalsePolyphenolic Profile and Antioxidant and Aortic Endothelium Effect of &lt;i&gt;Michay&lt;/i&gt; (&lt;i&gt;Berberis congestiflora&lt;/i&gt; Gay) Collected in the Araucania Region of Chile.Berries are an excellent source of bioactive compounds, particularly polyphenols, and have been widely used in folk medicine by the Mapuche people of southern Chile. In this study, a hydroalcoholic extract of <i>Berberis congestiflora</i> Gay (BE) was analyzed to determine its phytochemical composition and to evaluate its antioxidant capacity, vasorelaxant effects in rat aortas, and inhibitory activity on enzymes related to chronic non-communicable diseases, including exploration of a possible vasodilatory mechanism in isolated rat aortas. Antioxidant activity was assessed using Oxygen Radical Absorbance Capacity (ORAC), DPPH (2,2-diphenyl-1-picrylhydrazyl), and ABTS (2,2-azinobis-(3-ethylbenzothiazolin-6-sulfonic acid)) radical scavenging assays, as well as ferric reducing antioxidant pow2026-01-01T00:00:00Z2026 Jan2026-07-09T13:19:56.154Z2026-07-09T13:09:30.169ZS-EPMC128995934168151710.3390/plants15030352