{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["31(3)"],"submitter":["Castaneda-Espinoza JD"],"pubmed_abstract":["<b>Background</b>: Medicinal plants used in traditional Mexican medicine represent a valuable source of bioactive compounds with potential anticancer activity. Beyond cytotoxic potency, selectivity toward cancer cells over normal cells is a critical toxicological parameter for identifying safer therapeutic candidates. This study aimed to evaluate the selective cytotoxic and antiproliferative effects of extracts from four Mexican medicinal plants across human cancerous and non-cancerous cell lines. <b>Methods</b>: Hexane, acetone, and methanolic extracts from <i>Semialarium mexicanum</i>, <i>Eryngium heterophyllum</i>, <i>Piper auritum</i>, and <i>Cochlospermum vitifolium</i> were evaluated in a panel of human cancer cell lines and non-tumoral models, including primary human uterine fibrobl"],"journal":["Molecules (Basel, Switzerland)"],"pagination":["549"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12899643"],"repository":["biostudies-literature"],"pubmed_title":["Selective Cytotoxic and Antiproliferative Effects of Extracts from Four Mexican Medicinal Plants in Human Cancer and Non-Cancerous Cell Lines."],"pmcid":["PMC12899643"],"pubmed_authors":["Carranza Valencia E","Sanchez-Carranza JN","Salas-Vidal E","Uriostegui-Velarde JM","Anzurez Jimenez AN","Madariaga Sosa GA","Furuzawa-Carballeda J","Mojica Cardoso C","Marquina-Bahena S","Castaneda-Espinoza JD","Zagal Laguna KL","Guerrero-Alonso A","Alvarez Soto YA","Ayala Calvillo E"],"additional_accession":[]},"is_claimable":false,"name":"Selective Cytotoxic and Antiproliferative Effects of Extracts from Four Mexican Medicinal Plants in Human Cancer and Non-Cancerous Cell Lines.","description":"<b>Background</b>: Medicinal plants used in traditional Mexican medicine represent a valuable source of bioactive compounds with potential anticancer activity. Beyond cytotoxic potency, selectivity toward cancer cells over normal cells is a critical toxicological parameter for identifying safer therapeutic candidates. This study aimed to evaluate the selective cytotoxic and antiproliferative effects of extracts from four Mexican medicinal plants across human cancerous and non-cancerous cell lines. <b>Methods</b>: Hexane, acetone, and methanolic extracts from <i>Semialarium mexicanum</i>, <i>Eryngium heterophyllum</i>, <i>Piper auritum</i>, and <i>Cochlospermum vitifolium</i> were evaluated in a panel of human cancer cell lines and non-tumoral models, including primary human uterine fibrobl","dates":{"release":"2026-01-01T00:00:00Z","publication":"2026 Feb","modification":"2026-07-08T03:09:36.753Z","creation":"2026-07-08T03:08:32.21Z"},"accession":"S-EPMC12899643","cross_references":{"pubmed":["41683526"],"doi":["10.3390/molecules31030549"]}}