biostudies-literatureUnknown15(3)Perri MR<i>Glycyrrhiza glabra</i> L. (Fabaceae) is a plant species with already demonstrated countless biological properties and many more still to be discovered. Here, root sample extracts from different geographical areas were compared based on their phytochemical profiles and biological activities. Both raw and hydrolysate extracts, as well as 18β-glycyrrhetinic acid, glycyrrhizin, and isoliquiritigenin, considered as the main licorice secondary metabolites, were screened for antiproliferative and anti-migration properties in MCF-7, MDA-MB-231, A2780, HeLa, SiHa, and C33A breast and gynecological cancer cell lines. Hydrolysate extracts showed higher cytotoxicity than the raw extracts at the same final concentrations, 30 and 60 µg/mL, respectively. Among the standards, isoliquiritigenin showed tPlants (Basel, Switzerland)475https://www.ebi.ac.uk/biostudies/studies/S-EPMC12899981biostudies-literature&lt;i&gt;Glycyrrhiza glabra&lt;/i&gt; L. Extracts with Potential Antiproliferative and Anti-Migration Activities Against Breast and Gynecological Cancer Cell Lines.PMC12899981Perri MRVagvolgyi MStatti GZupko IBartha SHunyadi AMinorics RMarrelli MConforti FLupia Cfalse&lt;i&gt;Glycyrrhiza glabra&lt;/i&gt; L. Extracts with Potential Antiproliferative and Anti-Migration Activities Against Breast and Gynecological Cancer Cell Lines.<i>Glycyrrhiza glabra</i> L. (Fabaceae) is a plant species with already demonstrated countless biological properties and many more still to be discovered. Here, root sample extracts from different geographical areas were compared based on their phytochemical profiles and biological activities. Both raw and hydrolysate extracts, as well as 18β-glycyrrhetinic acid, glycyrrhizin, and isoliquiritigenin, considered as the main licorice secondary metabolites, were screened for antiproliferative and anti-migration properties in MCF-7, MDA-MB-231, A2780, HeLa, SiHa, and C33A breast and gynecological cancer cell lines. Hydrolysate extracts showed higher cytotoxicity than the raw extracts at the same final concentrations, 30 and 60 µg/mL, respectively. Among the standards, isoliquiritigenin showed t2026-01-01T00:00:00Z2026 Feb2026-07-07T03:12:02.172Z2026-07-07T03:08:38.543ZS-EPMC128999814168163810.3390/plants15030475