{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["White SL"],"funding":["BLRD VA","U.S. Department of Health & Human Services | NIH | National Cancer Institute (NCI)","Novo Nordisk Fonden (Novo Nordisk Foundation)","NCATS NIH HHS","NIA NIH HHS","U.S. Department of Health & Human Services | NIH | National Human Genome Research Institute (NHGRI)","National Institute for Health Research (NIHR)","NHGRI NIH HHS","Colorado University | UC Denver | Colorado Clinical and Translational Sciences Institute (CCTSI)","NCI NIH HHS","Wellcome Trust"],"pagination":["307-316"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12900643"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["58(2)"],"pubmed_abstract":["Thyroid diseases are common and highly heritable. We performed a meta-analysis of genome-wide association studies from 19 biobanks for five thyroid diseases: thyroid cancer (ThC), benign nodular goiter, Graves' disease, lymphocytic thyroiditis and primary hypothyroidism. We analyzed genetic association data from ~2.9 million genomes and identified 313 known and 570 new independent loci linked to thyroid diseases. We discovered genetic correlations between ThC, benign nodular goiter and autoimmune thyroid diseases (rg = 0.16-0.97). Telomere maintenance genes contributed to benign and malignant thyroid nodular disease risk, whereas cell cycle, DNA repair and damage response genes were associated with ThC. We propose a paradigm that explains genetic predisposition to benign and malignant thyr"],"journal":["Nature genetics"],"pubmed_title":["Global multi-ancestry genome-wide analyses identify genes and biological pathways associated with thyroid cancer and benign thyroid diseases."],"pmcid":["PMC12900643"],"funding_grant_id":["R00 HG012222","R00HG011898","R01 AG046938","R00 HG011898","1R21CA282380","NNF20OC0062294","UL1 TR002535","I01 BX006252","CO-J-24-170","R21 CA282380","NIHR203327"],"pubmed_authors":["Kaur V","Jee YH","Pattee J","Stefansson K","Straub P","Zhang H","Arehart CH","Martin AR","Pozdeyev N","Sanders AR","Pividori M","Rafaels N","Shriver C","Raeburn CD","Verma A","Jamil TL","Colorado Center for Personalized Medicine","Genes & Health Research Team","Medland SE","Evans LM","Moksnes MR","Chen Z","White SL","Wang Y","John C","Matsuda K","Fishbein L","Shortt JA","Phan MD","Bell CC","Chen J","Riedlinger G","Walters RG","Konrade I","Li L","Gignoux CR","Schweppe R","Chavan S","MacGregor S","Brock PL","Virtual Thyroid Biopsy Consortium","Penn Medicine BioBank","van Heel DA","Kraft P","Churchman ML","Lin M","Thorsteinsdottir U","Guare L","McCrary HC","Edge S","Neale BM","Tobin MD","Fisher MJ","Zollner S","Daly MJ","Global Biobank Meta-analysis Initiative","Whiteman DC","Hirbo J","Karaderi T","BioBank Japan Project","Salhia B","Brasher MS","Morris S","Haugen BR","Hendricks AE","Finer S","Cox NJ","Ringel MD","Bertucci-Richter E","Rounbehler RJ","Bocklage T","Preuss MH","Egan KM","Farlow JL","Zhou W","Kenny E","Brumpton BM","Peculis R","Mathur R","Crooks K","Fennessy B","Okada Y","Edris A","Chapman S","Namba S","Barrio M","Cole JB","Asvold BO","Rovite V","Mulford AJ","Williams AT"],"additional_accession":[]},"is_claimable":false,"name":"Global multi-ancestry genome-wide analyses identify genes and biological pathways associated with thyroid cancer and benign thyroid diseases.","description":"Thyroid diseases are common and highly heritable. We performed a meta-analysis of genome-wide association studies from 19 biobanks for five thyroid diseases: thyroid cancer (ThC), benign nodular goiter, Graves' disease, lymphocytic thyroiditis and primary hypothyroidism. We analyzed genetic association data from ~2.9 million genomes and identified 313 known and 570 new independent loci linked to thyroid diseases. We discovered genetic correlations between ThC, benign nodular goiter and autoimmune thyroid diseases (rg = 0.16-0.97). Telomere maintenance genes contributed to benign and malignant thyroid nodular disease risk, whereas cell cycle, DNA repair and damage response genes were associated with ThC. We propose a paradigm that explains genetic predisposition to benign and malignant thyr","dates":{"release":"2026-01-01T00:00:00Z","publication":"2026 Feb","modification":"2026-07-16T21:25:49.461Z","creation":"2026-07-10T03:15:53.507Z"},"accession":"S-EPMC12900643","cross_references":{"pubmed":["41644669"],"doi":["10.1038/s41588-025-02483-w"]}}