biostudies-literatureUnknown18Kao YL<h4>Background</h4>Contralateral recurrence of upper-tract urothelial carcinoma (UTUC) presents a clinical challenge, with limited evidence regarding optimal surgical management.<h4>Objective</h4>To compare oncological outcomes among patients with contralateral UTUC recurrence managed by second nephroureterectomy (NUR) or nephron-sparing surgery (NSS), relative to those undergoing primary NUR.<h4>Design</h4>A multicentre retrospective cohort study.<h4>Methods</h4>In this multicentre retrospective cohort, 3159 patients diagnosed with UTUC between 2018 and 2024 in the Taiwanese UTUC Registry were analysed. Patients undergoing curative-intent surgery were grouped as follows: unilateral UTUC treated with primary NUR; contralateral recurrence treated with a second NUR; and contralateral recurreTherapeutic advances in urology17562872261419593https://www.ebi.ac.uk/biostudies/studies/S-EPMC12901921biostudies-literatureContralateral recurrent upper-tract urothelial carcinoma after curative surgery: a multicentre retrospective cohort study.PMC12901921Tsai CYChen IAOu CHWu HCHuang CYChang CHWu WJLi CCTsai YCCheng PYKao YLYu CCfalseContralateral recurrent upper-tract urothelial carcinoma after curative surgery: a multicentre retrospective cohort study.<h4>Background</h4>Contralateral recurrence of upper-tract urothelial carcinoma (UTUC) presents a clinical challenge, with limited evidence regarding optimal surgical management.<h4>Objective</h4>To compare oncological outcomes among patients with contralateral UTUC recurrence managed by second nephroureterectomy (NUR) or nephron-sparing surgery (NSS), relative to those undergoing primary NUR.<h4>Design</h4>A multicentre retrospective cohort study.<h4>Methods</h4>In this multicentre retrospective cohort, 3159 patients diagnosed with UTUC between 2018 and 2024 in the Taiwanese UTUC Registry were analysed. Patients undergoing curative-intent surgery were grouped as follows: unilateral UTUC treated with primary NUR; contralateral recurrence treated with a second NUR; and contralateral recurre2026-01-01T00:00:00Z2026 Jan-Dec2026-07-15T22:02:38.969Z2026-07-09T13:09:37.333ZS-EPMC129019214169426510.1177/17562872261419593