biostudies-literatureUnknown10Bai Y<h4>Background</h4>Idiopathic esophageal perforation complicated by thyroid abscess formation constitutes a rare and severe clinical emergency. The precise pathogenesis of this condition remains elusive, and its potential for recurrence necessitates further investigation to establish evidence-based, personalized therapeutic protocols.<h4>Case description</h4>We present a case of a 41-year-old female who initially presented with a spontaneous cervical esophageal perforation associated with an ipsilateral thyroid abscess. The patient underwent prompt surgical intervention consisting of meticulous debridement and drainage, facilitated by intraoperative neuromonitoring to preserve recurrent laryngeal nerve function and thyroid integrity. The postoperative course was uneventful, and the patientAME case reports1https://www.ebi.ac.uk/biostudies/studies/S-EPMC12902160biostudies-literatureRecurrent idiopathic esophageal perforation complicated by thyroid abscess: a case report and review of the literature.PMC12902160Sheng JHe YZeng ZWang WLuo HBai YfalseRecurrent idiopathic esophageal perforation complicated by thyroid abscess: a case report and review of the literature.<h4>Background</h4>Idiopathic esophageal perforation complicated by thyroid abscess formation constitutes a rare and severe clinical emergency. The precise pathogenesis of this condition remains elusive, and its potential for recurrence necessitates further investigation to establish evidence-based, personalized therapeutic protocols.<h4>Case description</h4>We present a case of a 41-year-old female who initially presented with a spontaneous cervical esophageal perforation associated with an ipsilateral thyroid abscess. The patient underwent prompt surgical intervention consisting of meticulous debridement and drainage, facilitated by intraoperative neuromonitoring to preserve recurrent laryngeal nerve function and thyroid integrity. The postoperative course was uneventful, and the patient2026-01-01T00:00:00Z20262026-07-15T21:57:53.785Z2026-07-09T13:09:22.751ZS-EPMC129021604169618410.21037/acr-20251-260